U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2C2H3O2.Al.HO
Molecular Weight 162.0769
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALUMINUM SUBACETATE

SMILES

[OH-].[Al+3].CC([O-])=O.CC([O-])=O

InChI

InChIKey=HQQUTGFAWJNQIP-UHFFFAOYSA-K
InChI=1S/2C2H4O2.Al.H2O/c2*1-2(3)4;;/h2*1H3,(H,3,4);;1H2/q;;+3;/p-3

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Curator's Comment: Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DOMEBORO

Approved Use

Temporarily relieves minor skin irritations due to: – Poison ivy | – Poison oak – Poison sumac | – Insect bites – Athlete’s foot | – Rashes caused by soaps, detergents, cosmetics, or jewelry
Curative
DOMEBORO

Approved Use

This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.
PubMed

PubMed

TitleDatePubMed
The ineffectiveness of aluminum subacetate in rheumatoid arthritis.
1948 Apr 8
Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells.
1987 Nov 15
Aluminum fluoride inhibition of glucocorticoid receptor inactivation and transformation.
1990 Apr 10
Plasma renin activity in shock due to aluminium phosphide poisoning.
1990 Jun
Hypermagnesemia following aluminum phosphide poisoning.
1991 Feb
Requirement for intramolecular domain interaction in activation of G protein alpha subunit by aluminum fluoride and GDP but not by GTP gamma S.
1994 Nov 25
Manipulation of B cell antigen receptor tyrosine phosphorylation using aluminum fluoride and sodium orthovanadate.
1995 Nov
Effect of aluminum phosphide on blood glucose level.
1999 Feb
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.
1999 May
Intravascular hemolysis in aluminium phosphide poisoning.
1999 Sep
Effect of N-acetylcysteine and L-NAME on aluminium phosphide induced cardiovascular toxicity in rats.
2001 Apr
Cholinesterase inhibition by aluminium phosphide poisoning in rats and effects of atropine and pralidoxime chloride.
2001 Jan
Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information.
2002
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite.
2003
The role of metals in neurodegenerative processes: aluminum, manganese, and zinc.
2003 Nov 15
Parenteral nutrition-associated cholestasis in neonates: the role of aluminum.
2003 Sep
Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.
2005 Nov
Some aspects of astroglial functions and aluminum implications for neurodegeneration.
2006 Aug 30
Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents.
2006 Nov
Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration.
2006 Nov
The role of aluminum and copper on neuroinflammation and Alzheimer's disease.
2006 Nov
Effect of acute aluminum phosphide exposure on rats: a biochemical and histological correlation.
2012 Nov 23
New insight into artifactual phenomena during in vitro toxicity assessment of engineered nanoparticles: study of TNF-α adsorption on alumina oxide nanoparticle.
2013 Apr
Pesticide exposure and depression among male private pesticide applicators in the agricultural health study.
2014 Sep
Molecular basis of carcinogenicity of tungsten alloy particles.
2015 Mar 15
Patents

Sample Use Guides

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use
Route of Administration: Topical
Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.
Name Type Language
ALUMINUM SUBACETATE
II   MI   USP  
Common Name English
ALUMINIUM DIACETATE
WHO-DD  
Systematic Name English
ALUMINUM SUBACETATE [MI]
Common Name English
ALUMINUM SUBACETATE [USP IMPURITY]
Common Name English
ALUMINUM, BIS(ACETATO-.KAPPA.O)HYDROXY-
Common Name English
ALUMINUM DIACETATE [INCI]
Common Name English
ALUMINUM, BIS(ACETATO-O)HYDROXY-
Common Name English
ALUMINUM SUBACETATE [II]
Common Name English
ALUMINUM DIACETATE [VANDF]
Common Name English
Aluminium diacetate [WHO-DD]
Common Name English
ALUMINIUM, BIS(ACETATO-O)HYDROXY-
Common Name English
ALUMINUM ACETATE BASIC
Common Name English
ALUMINUM DIACETATE
INCI   VANDF  
INCI  
Official Name English
ALUMINIUM DIACETATE HYDROXIDE
Systematic Name English
Bis(acetato)hydroxyaluminum
Common Name English
ALUMINIUM, BIS(ACETATO-.KAPPA.O)HYDROXY-
Common Name English
BASIC ALUMINIUM ACETATE
Common Name English
BASIC ALUMINUM ACETATE
Common Name English
ALUMINUM HYDROXIDE ACETATE (1:1:2)
Systematic Name English
ALUMINIUM HYDROXYDIACETATE
Common Name English
ALUMINIUM SUBACETATE
Common Name English
BIS(ACETATO)HYDROXYALUMINIUM
Common Name English
Code System Code Type Description
EVMPD
SUB12821MIG
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
CONCEPT Industrial Aid
SMS_ID
300000031249
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY
ECHA (EC/EINECS)
205-518-2
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY
FDA UNII
FGL8577C9S
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY
DRUG BANK
DB15679
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY
DAILYMED
FGL8577C9S
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY
PUBCHEM
10197832
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY
MERCK INDEX
m1629
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
ALUMINIUM DIACETATE
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY
EVMPD
SUB91977
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY
EPA CompTox
DTXSID7044552
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY
CAS
142-03-0
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY
RXCUI
235461
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY RxNorm
NCI_THESAURUS
C77451
Created by admin on Fri Dec 15 15:54:30 GMT 2023 , Edited by admin on Fri Dec 15 15:54:30 GMT 2023
PRIMARY