ALUMINUM SUBACETATE

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C2H3O2.Al.HO
Molecular Weight	162.0769
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[OH-].[Al+3].CC([O-])=O.CC([O-])=O

InChI

InChIKey=HQQUTGFAWJNQIP-UHFFFAOYSA-K

InChI=1S/2C2H4O2.Al.H2O/c2*1-2(3)4;;/h2*1H3,(H,3,4);;1H2/q;;+3;/p-3

HIDE SMILES / InChI

Description
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cell membrane 42 Target ID: CHEMBL2364031 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22718290 \| https://www.ncbi.nlm.nih.gov/pubmed/10211213	Interacts 323
vasoconstriction 32 Target ID: GO:0042310 Sources: https://www.drugs.com/monograph/aluminum-acetate.html	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Itching 54 Sources: http://www.domeboro.com/about-domeboro/ https://www.drugs.com/monograph/aluminum-acetate.html	Primary		Approved 8429	DOMEBORO Approved Use Temporarily relieves minor skin irritations due to: – Poison ivy \| – Poison oak – Poison sumac \| – Insect bites – Athlete’s foot \| – Rashes caused by soaps, detergents, cosmetics, or jewelry
Otitis 40 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15516810 https://www.ncbi.nlm.nih.gov/pubmed/14724484 https://www.drugs.com/monograph/aluminum-acetate.html	Curative		Approved 8429	DOMEBORO Approved Use This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.

PubMed

Title	Date	PubMed
Cardiovascular manifestations of aluminium phosphide intoxication.	1989 Sep	2632560
The antibacterial activity of acetic acid and Burow's solution as topical otological preparations.	1998 Oct	10211213
Effect of aluminum phosphide on blood glucose level.	1999 Feb	9949483
Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information.	2002	12511178
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite.	2003	12851164
The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells.	2004 Feb 13	14960311
Aluminum: new recognition of an old problem.	2005 Dec	16198633
Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.	2005 Nov	16308486
An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling.	2006 Jan	16280360
Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.	2007 Oct	17931164
Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet.	2007 Sep-Oct	17870524
Hyperglycemia in acute aluminum phosphide poisoning as a potential prognostic factor.	2008 Jul	18829736
Aluminum phosphide fatalities at mild exertion in asymptomatic children: a clue to understand the variations of the autopsy findings.	2009 Aug	19573839
Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): the key metric of dose is particle mass and not particle surface area.	2009 May 17	19428954
Altered glucose homeostasis in response to aluminium phosphide induced cellular oxygen deficit in rat.	2010 Jul	20929055
Blood levels of methemoglobin in patients with aluminum phosphide poisoning and its correlation with patient's outcome.	2011 Mar	21057909
Molecular basis of carcinogenicity of tungsten alloy particles.	2015 Mar 15	25620057

Patents

Sample Use Guides

In Vivo Use Guide

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use

Route of Administration: Topical

In Vitro Use Guide

Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.

Name

Type

Language

ALUMINUM SUBACETATE

Common Name

English

ALUMINIUM DIACETATE

Systematic Name

English

ALUMINUM SUBACETATE [MI]

Common Name

English

ALUMINUM SUBACETATE [USP IMPURITY]

Common Name

English

ALUMINUM, BIS(ACETATO-.KAPPA.O)HYDROXY-

Common Name

English

ALUMINUM DIACETATE [INCI]

Common Name

English

ALUMINUM, BIS(ACETATO-O)HYDROXY-

Common Name

English

ALUMINUM SUBACETATE [II]

Common Name

English

ALUMINUM DIACETATE [VANDF]

Common Name

English

Aluminium diacetate [WHO-DD]

Common Name

English

ALUMINIUM, BIS(ACETATO-O)HYDROXY-

Common Name

English

ALUMINUM ACETATE BASIC

Common Name

English

ALUMINUM DIACETATE

Official Name

English

ALUMINIUM DIACETATE HYDROXIDE

Systematic Name

English

Bis(acetato)hydroxyaluminum

Common Name

English

ALUMINIUM, BIS(ACETATO-.KAPPA.O)HYDROXY-

Common Name

English

BASIC ALUMINIUM ACETATE

Common Name

English

BASIC ALUMINUM ACETATE

Common Name

English

ALUMINUM HYDROXIDE ACETATE (1:1:2)

Systematic Name

English

ALUMINIUM HYDROXYDIACETATE

Common Name

English

ALUMINIUM SUBACETATE

Common Name

English

BIS(ACETATO)HYDROXYALUMINIUM

Common Name

English

Code System Code Type Description

EVMPD

SUB12821MIG