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Details

Stereochemistry ACHIRAL
Molecular Formula 2C5H14NO.MoS4
Molecular Weight 432.54
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIOMOLIBDATE CHOLINE

SMILES

[S-][Mo]([S-])(=S)=S.C[N+](C)(C)CCO.C[N+](C)(C)CCO

InChI

InChIKey=NEYVHGQOGHJAAD-UHFFFAOYSA-N
InChI=1S/2C5H14NO.Mo.4S/c2*1-6(2,3)4-5-7;;;;;/h2*7H,4-5H2,1-3H3;;;;;/q2*+1;;;;2*-1

HIDE SMILES / InChI
Tiomolibdic acid salt, Bis-choline tetrathiomolybdate (ATN-224, WTX-101), is under investigation as a therapy against different cancers and Wilson’s disease (WD). ATN-224 is a second-generation analog of ammonium tetrathiomolybdate. ATN-224 is a novel copper chelator. ATN-224 inhibits CuZn superoxide dismutase 1 (SOD1) leading to antiangiogenic and antitumor effects. Strategically tailoring combination regimens that include ATN-224 and target ROS may be a viable approach to advance the treatment of melanoma. ATN-224 is in phase III clinical trial for the treatment of Hepatolenticular degeneration. WTX-101 is in phase II clinical trials for the treatment of Wilson's disease. Once daily WTX-101 treatment over 24 weeks improved neurologic disease, hepatic status and copper control in newly diagnosed WD patients. WTX-101 appears well tolerated. Drug-induced, paradoxical, neurological deterioration was not observed. This compound has received orphan drug designation in both the United States and the European Union. WTX-101 was originally discovered by University of Michigan and now is being developed by Wilson Therapeutics by acquisition.

Approval Year

PubMed

PubMed

TitleDatePubMed
Development of a new bimodal imaging methodology: a combination of fluorescence microscopy and high-resolution secondary ion mass spectrometry.
2010 Oct
Changes in PSA kinetics predict metastasis- free survival in men with PSA-recurrent prostate cancer treated with nonhormonal agents: combined analysis of 4 phase II trials.
2012 Mar 15
Copper chelation enhances antitumor efficacy and systemic delivery of oncolytic HSV.
2012 Sep 15
The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma.
2014 Jul
Targeting antioxidants for cancer therapy.
2014 Nov 1
ATN-224 enhances antitumor efficacy of oncolytic herpes virus against both local and metastatic head and neck squamous cell carcinoma.
2015
Change in PSA velocity is a predictor of overall survival in men with biochemically-recurrent prostate cancer treated with nonhormonal agents: combined analysis of four phase-2 trials.
2015 Mar
Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells.
2015 Oct
Name Type Language
TIOMOLIBDATE CHOLINE
USAN  
Official Name English
ALXN-1840
Preferred Name English
Bis(choline) tetrathiomolybdate [WHO-DD]
Common Name English
TIOMOLIBDATE CHOLINE [USAN]
Common Name English
ETHANAMINIUM, 2-HYDROXY-N,N,N-TRIMETHYL-, (T-4)-TETRATHIOXOMOLYBDATE(2-) (2:1)
Common Name English
ATN-224
Code English
BIS(CHOLINE)TETRATHIOMOLYBDATE
Common Name English
TIOMOLIBDATE CHOLINE [JAN]
Common Name English
ALXN1840
Code English
CHOLINE TETRATHIOMOLYBDATE
Common Name English
WTX-101
Code English
BIS-CHOLINE TETRATHIOMOLYBDATE
Common Name English
WTX101
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 569516
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
FDA ORPHAN DRUG 346511
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
NCI_THESAURUS C471
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
NCI_THESAURUS C1742
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
FDA ORPHAN DRUG 733720
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
EU-Orphan Drug EU/3/12/1089
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID301031607
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
PRIMARY
EVMPD
SUB182753
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
PRIMARY
FDA UNII
FD57A79R4P
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
PRIMARY
CAS
649749-10-0
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
PRIMARY
USAN
GH-166
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
PRIMARY
PUBCHEM
18442052
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
PRIMARY
NCI_THESAURUS
C62514
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
PRIMARY
SMS_ID
300000011152
Created by admin on Fri Dec 15 15:29:46 GMT 2023 , Edited by admin on Fri Dec 15 15:29:46 GMT 2023
PRIMARY