Details
Stereochemistry | ACHIRAL |
Molecular Formula | 2C5H14NO.MoS4 |
Molecular Weight | 432.54 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[S-][Mo]([S-])(=S)=S.C[N+](C)(C)CCO.C[N+](C)(C)CCO
InChI
InChIKey=NEYVHGQOGHJAAD-UHFFFAOYSA-N
InChI=1S/2C5H14NO.Mo.4S/c2*1-6(2,3)4-5-7;;;;;/h2*7H,4-5H2,1-3H3;;;;;/q2*+1;;;;2*-1
Tiomolibdic acid salt, Bis-choline tetrathiomolybdate (ATN-224, WTX-101), is under investigation as a therapy against different cancers and Wilson’s disease (WD). ATN-224 is a second-generation analog of ammonium tetrathiomolybdate. ATN-224 is a novel copper chelator. ATN-224 inhibits CuZn superoxide dismutase 1 (SOD1) leading to antiangiogenic and antitumor effects. Strategically tailoring combination regimens that include ATN-224 and target ROS may be a viable approach to advance the treatment of melanoma. ATN-224 is in phase III clinical trial for the treatment of Hepatolenticular degeneration. WTX-101 is in phase II clinical trials for the treatment of Wilson's disease. Once daily WTX-101 treatment over 24 weeks improved neurologic disease, hepatic status and copper control in newly diagnosed WD patients. WTX-101 appears well tolerated. Drug-induced, paradoxical, neurological deterioration was not observed. This compound has received orphan drug designation in both the United States and the European Union. WTX-101 was originally discovered by University of Michigan and now is being developed by Wilson Therapeutics by acquisition.
Approval Year
PubMed
Title | Date | PubMed |
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Development of a new bimodal imaging methodology: a combination of fluorescence microscopy and high-resolution secondary ion mass spectrometry. | 2010 Oct |
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Changes in PSA kinetics predict metastasis- free survival in men with PSA-recurrent prostate cancer treated with nonhormonal agents: combined analysis of 4 phase II trials. | 2012 Mar 15 |
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Copper chelation enhances antitumor efficacy and systemic delivery of oncolytic HSV. | 2012 Sep 15 |
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The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma. | 2014 Jul |
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Targeting antioxidants for cancer therapy. | 2014 Nov 1 |
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ATN-224 enhances antitumor efficacy of oncolytic herpes virus against both local and metastatic head and neck squamous cell carcinoma. | 2015 |
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Change in PSA velocity is a predictor of overall survival in men with biochemically-recurrent prostate cancer treated with nonhormonal agents: combined analysis of four phase-2 trials. | 2015 Mar |
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Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells. | 2015 Oct |
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Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
569516
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FDA ORPHAN DRUG |
346511
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NCI_THESAURUS |
C471
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NCI_THESAURUS |
C1742
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FDA ORPHAN DRUG |
733720
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EU-Orphan Drug |
EU/3/12/1089
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DTXSID301031607
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SUB182753
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FD57A79R4P
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649749-10-0
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GH-166
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18442052
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C62514
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300000011152
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ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD