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Details

Stereochemistry ACHIRAL
Molecular Formula C24H28N2O3
Molecular Weight 392.4907
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ADL-5859

SMILES

CCN(CC)C(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=CC=CC(O)=C24

InChI

InChIKey=OPIKUXLJQFYMSC-UHFFFAOYSA-N
InChI=1S/C24H28N2O3/c1-3-26(4-2)23(28)18-10-8-17(9-11-18)19-16-24(12-14-25-15-13-24)29-21-7-5-6-20(27)22(19)21/h5-11,16,25,27H,3-4,12-15H2,1-2H3

HIDE SMILES / InChI
ADL5859 (or ADL-5859) is Adolor Corporation developed a novel, oral compound that targets the delta opioid receptor. Delta receptor agonists are thought to offer benefits over other approaches to the management of pain. ADL-5859 was in the phase II of clinical trial for the treatment of neuropathic pain, acute pain, and pain due to osteoarthritis of the knee and for patients with osteoarthritis. Further development of this drug as potential pain treatments was discontinued.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed

Sample Use Guides

single dose: 30, 100, 200 mg
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
ADL-5859
Common Name English
BENZAMIDE, N,N-DIETHYL-4-(5-HYDROXYSPIRO(2H-1-BENZOPYRAN-2,4'-PIPERIDIN)-4-YL)-
Systematic Name English
Code System Code Type Description
FDA UNII
FA554TW3UP
Created by admin on Sat Dec 16 08:18:26 GMT 2023 , Edited by admin on Sat Dec 16 08:18:26 GMT 2023
PRIMARY
CAS
850305-06-5
Created by admin on Sat Dec 16 08:18:26 GMT 2023 , Edited by admin on Sat Dec 16 08:18:26 GMT 2023
PRIMARY
PUBCHEM
11417954
Created by admin on Sat Dec 16 08:18:26 GMT 2023 , Edited by admin on Sat Dec 16 08:18:26 GMT 2023
PRIMARY