Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H25F3N2OS |
| Molecular Weight | 434.5196 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
c1ccc2c(c1)/C(=C(\[H])/CCN3CCN(CC3)CCO)/c4cc(ccc4S2)C(F)(F)F
InChI
InChIKey=NJMYODHXAKYRHW-DVZOWYKESA-N
InChI=1S/C23H25F3N2OS/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29/h1-2,4-8,16,29H,3,9-15H2/b18-5-
CNS Activity
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL217 Sources: DOI: 10.1016/B978-008055232-3.61770-2 |
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Target ID: CHEMBL2095200 |
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Target ID: CHEMBL2094251 |
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Target ID: CHEMBL231 |
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Target ID: CHEMBL2094109 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | FLUANXOL Approved UseFlupentixol Decanoate Injection and Flupentixol Dihydrochloride Tablets
Indication: Schizophrenia and allied psychoses, especially with symptoms such as hallucinations, delusions and thought disturbances along with apathy, lowered mood and withdrawal. |
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| Primary | FLUANXOL Approved UseFluanxol is used to treat depression in patients who may, or may not, also be showing signs of anxiety. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Flupenthixol and trifluoperazine: a double-blind investigation in the treatment of schizophrenics. | 1971 Nov |
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| A comparative trail of fluphenazine decanoate and flupenthixol decanoate. | 1975 Feb |
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| A controlled comparison of flupenthixol and amitriptyline in depressed outpatients. | 1976 May 8 |
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| Depot injections and tardive dyskinesia. | 1978 Oct |
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| Persistent involuntary movements after treatment with flupenthixol. | 1981 May 30 |
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| Effects of chronic treatment with antidepressants on aggressiveness induced by clonidine in mice. | 1982 |
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| Abnormal involuntary movements: a study of dopaminergic receptor interaction. | 1983 |
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| Flupenthixol versus haloperidol in acute psychosis. | 1983 |
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| Neuroleptic malignant syndrome. | 1984 Jun 23 |
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| Pharmacology in vivo of the phenylindan derivative, Lu 19-005, a new potent inhibitor of dopamine, noradrenaline and 5-hydroxytryptamine uptake in rat brain. | 1985 Apr |
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| The selective dopamine D2 receptor antagonist raclopride discriminates between dopamine-mediated motor functions. | 1986 |
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| The antibacterial effect of selected phenothiazines and thioxanthenes on slow-growing mycobacteria. | 1986 Dec |
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| [D-TRP11]-neurotensin, unlike alpha-flupenthixol, may not block amphetamine-induced hyperactivity in rats. | 1989 Mar |
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| Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. | 1991 Apr 18 |
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| Effect of selected neuroleptic agents and stereo-isomeric analogues on virus and eukaryotic cells. | 1991 May |
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| [Pharmacotoxic psychosis and extrapyramidal motor syndrome. A case of acute adverse effect of fluoxetine and flupenthixol]. | 1992 Sep |
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| Strain differences in clonidine-induced aggressiveness in mice and its interaction with the dopamine system. | 1993 Apr |
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| Depot flupenthixol-induced mania. | 1993 Jun |
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| Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. | 1994 Feb 1 |
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| Expression and pharmacological characterization of the human D3 dopamine receptor. | 1994 Jan |
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| Convulsions after enflurane in a schizophrenic patient receiving neuroleptics. | 1994 May |
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| High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype. | 1994 Nov 11 |
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| Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine. | 1995 Sep 5 |
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| Mitochondrial involvement in schizophrenia and other functional psychoses. | 1996 Sep |
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| Tolerability of low dose neuroleptics: a case control study of flupenthixol. | 1997 Nov |
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| Flupenthixol treatment for cocaine abusers with schizophrenia: a pilot study. | 1998 Aug |
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| Effects of flupenthixol and quadazocine on self-administration of speedball combinations of cocaine and heroin by rhesus monkeys. | 1999 Oct |
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| Inhibition of HIV replication by neuroleptic agents and their potential use in HIV infected patients with AIDS related dementia. | 2000 Apr |
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| Effect of flupenthixol on subjective and cardiovascular responses to intravenous cocaine in humans. | 2001 Nov 1 |
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| Association between flupenthixol treatment and emergence of manic symptoms. | 2002 Oct |
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| Nonalcoholic steatohepatitis: a possible side effect of atypical antipsychotics. | 2003 Jul |
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| Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site. | 2003 Jun 6 |
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| Encephalopathy and myoclonus triggered by valproic acid. | 2004 Sep |
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| [Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations]. | 2006 Jun |
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| Post-training intra-striatal scopolamine or flupenthixol impairs radial maze learning in rats. | 2006 Jun 3 |
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| Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys. | 2007 Aug |
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| Cell specific dopamine modulation of the transient potassium current in the pyloric network by the canonical D1 receptor signal transduction cascade. | 2010 Aug |
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| The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates. | 2012 Mar |
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| Antitubercular pharmacodynamics of phenothiazines. | 2013 Apr |
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| Phenothiazines inhibit hepatitis C virus entry, likely by increasing the fluidity of cholesterol-rich membranes. | 2013 Jun |
Patents
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| Code System | Code | Type | Description | ||
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53772-82-0
Created by
admin on Sat Jun 26 07:22:19 UTC 2021 , Edited by admin on Sat Jun 26 07:22:19 UTC 2021
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PRIMARY | |||
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FA0UYH6QUO
Created by
admin on Sat Jun 26 07:22:19 UTC 2021 , Edited by admin on Sat Jun 26 07:22:19 UTC 2021
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258-756-4
Created by
admin on Sat Jun 26 07:22:19 UTC 2021 , Edited by admin on Sat Jun 26 07:22:19 UTC 2021
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5281881
Created by
admin on Sat Jun 26 07:22:19 UTC 2021 , Edited by admin on Sat Jun 26 07:22:19 UTC 2021
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53772-82-0
Created by
admin on Sat Jun 26 07:22:19 UTC 2021 , Edited by admin on Sat Jun 26 07:22:19 UTC 2021
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PRIMARY |
SUBSTANCE RECORD
