Details
Stereochemistry | ACHIRAL |
Molecular Formula | C31H25F3N2O4 |
Molecular Weight | 546.5364 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=CC(C(=O)NC2=CC=C3CN(CCC3=C2)C(=O)OC4=CC=CC=C4)=C1C5=CC=C(C=C5)C(F)(F)F
InChI
InChIKey=AZUIUVJESCFSLJ-UHFFFAOYSA-N
InChI=1S/C31H25F3N2O4/c1-39-27-9-5-8-26(28(27)20-10-13-23(14-11-20)31(32,33)34)29(37)35-24-15-12-22-19-36(17-16-21(22)18-24)30(38)40-25-6-3-2-4-7-25/h2-15,18H,16-17,19H2,1H3,(H,35,37)
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P55157 Gene ID: 4547.0 Gene Symbol: MTTP Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21406547 |
8.0 nM [IC50] |
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913541-47-6
Created by
admin on Sat Dec 16 01:41:13 GMT 2023 , Edited by admin on Sat Dec 16 01:41:13 GMT 2023
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53497429
Created by
admin on Sat Dec 16 01:41:13 GMT 2023 , Edited by admin on Sat Dec 16 01:41:13 GMT 2023
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F84YQX13FV
Created by
admin on Sat Dec 16 01:41:13 GMT 2023 , Edited by admin on Sat Dec 16 01:41:13 GMT 2023
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SLX-4090
Created by
admin on Sat Dec 16 01:41:13 GMT 2023 , Edited by admin on Sat Dec 16 01:41:13 GMT 2023
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PRIMARY | Funding Source - FDA OOPDPurpose: This study is being done to find out whether an investigational (not approved by FDA ) drug called SLx-4090 or Orlistat (FDA approved medication for weight loss) when given alone or in combination can treat the high blood fat (elevated triglycerides)levels found in the condition Type 1 Hyperlipoproteinemia (T1HLP) better or more safely than low fat diet alone, the current standard medical care.It is also not clear whether Orlistat, that is FDA approved for weight loss, is effective in lowering blood fat levels in patients with Type 1 hyperlipoproteinemia (T1HLP). The researchers are interested in learning whether any one of these drugs when given alone or in combination is more effective and safe in treating T1HLP. | ||
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DB05678
Created by
admin on Sat Dec 16 01:41:13 GMT 2023 , Edited by admin on Sat Dec 16 01:41:13 GMT 2023
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PRIMARY |
ACTIVE MOIETY