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Details

Stereochemistry RACEMIC
Molecular Formula C13H14Cl2O3
Molecular Weight 289.154
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CIPROFIBRATE

SMILES

CC(C)(OC1=CC=C(C=C1)C2CC2(Cl)Cl)C(O)=O

InChI

InChIKey=KPSRODZRAIWAKH-UHFFFAOYSA-N
InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)

HIDE SMILES / InChI

Description

Ciprofibrate is an orally active phenoxyisobutyrate hypolipidemic compound. It acts by activating peroxisome proliferator activated receptor alpha. Ciprofibrate is efficacious for the correction of hyperlipidaemias.

Originator

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
58.0 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
CIPROFIBRATE
PubMed

PubMed

TitleDatePubMed
Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.
2005 Aug 1
Ciprofibrate stimulates the gastrin-producing cell by acting luminally on antral PPAR-alpha.
2005 Dec
[A case of Parkinsonian syndrome, cognitive impairment and hyperammonemia induced by divalproate sodium prescribed for bipolar disorder].
2005 Jan-Feb
The effect of ciprofibrate on flow-mediated dilation and inflammatory markers in patients with combined hyperlipidemia.
2005 Jul-Aug
Induction of pancreatic acinar cell proliferation by thyroid hormone.
2005 Jun
Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate.
2005 May 26
Gene expression profiling of the PPAR-alpha agonist ciprofibrate in the cynomolgus monkey liver.
2005 Nov
Monocyte release of tumor necrosis factor-alpha and interleukin-1beta in primary type IIa and IIb dyslipidemic patients treated with statins or fibrates.
2005 Sep
Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways.
2005 Sep
Characterization of liver function in transdifferentiated hepatocytes.
2006 Jan
Patents

Sample Use Guides

In Vivo Use Guide
The recommended dosage is one tablet (100mg ciprofibrate) per day.
Route of Administration: Oral
In Vitro Use Guide
0.25 mM ciprofibrate was found to increase the phosphorylation of epidermal-growth-factor receptor in isolated rat hepatocytes
Name Type Language
CIPROFIBRATE
EP   INN   MART.   MI   USAN   WHO-DD  
INN   USAN  
Official Name English
PROPANOIC ACID, 2-(4-(2,2-DICHLOROCYCLOPROPYL)PHENOXY)-2-METHYL-
Common Name English
CIPROFIBRATE [USAN]
Common Name English
CIPROFIBRATE [MART.]
Common Name English
CIPROFIBRATE [MI]
Common Name English
CIPROFIBRATE [WHO-DD]
Common Name English
2-(P-(2,2-DICHLOROCYCLOPROPYL)PHENOXY)-2-METHYLPROPIONIC ACID
Common Name English
WIN-35833
Code English
WIN 35833
Code English
CIPROFIBRATE [INN]
Common Name English
CIPROFIBRATE [EP]
Common Name English
Classification Tree Code System Code
WHO-VATC QC10AB08
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
WHO-ATC C10AB08
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
Code System Code Type Description
CAS
52214-84-3
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
PRIMARY
PUBCHEM
2763
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
PRIMARY SWITZERF
NCI_THESAURUS
C87471
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
PRIMARY
WIKIPEDIA
CIPROFIBRATE
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
PRIMARY
ChEMBL
CHEMBL557555
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
PRIMARY
MESH
C019304
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
PRIMARY
ECHA (EC/EINECS)
257-744-6
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
PRIMARY
MERCK INDEX
M3582
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
PRIMARY Merck Index
EPA CompTox
52214-84-3
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
PRIMARY
EVMPD
SUB07469MIG
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
PRIMARY
RXCUI
21149
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
PRIMARY RxNorm
INN
4057
Created by admin on Tue Mar 06 12:21:56 UTC 2018 , Edited by admin on Tue Mar 06 12:21:56 UTC 2018
PRIMARY