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Details

Stereochemistry ACHIRAL
Molecular Formula 2Al.8Na.4O4P.2HO4P
Molecular Weight 809.7253
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -2

SHOW SMILES / InChI
Structure of KASAL

SMILES

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].OP([O-])([O-])=O.OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

InChI

InChIKey=BGLAPYTXCULTEW-UHFFFAOYSA-A
InChI=1S/2Al.8Na.6H3O4P/c;;;;;;;;;;6*1-5(2,3)4/h;;;;;;;;;;6*(H3,1,2,3,4)/q2*+3;8*+1;;;;;;/p-16

HIDE SMILES / InChI

Description

Kasal (Sodium Aluminum Phosphate, basic, non-leavening) is a white odorless powder comprised of an autogenous mixture of alkaline sodium aluminum phosphate and dibasic sodium phosphate. Kasal is used primarily as an emulsifier in the production of processed cheese.

CNS Activity

CNS Penetrant
2554
Curator's Comment: Aluminum can be detected in the brain of Kasal treated dogs.

Approval Year

1942
36
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Toxicity and aluminium concentration in bone following dietary administration of two sodium aluminium phosphate formulations in rats.
1987 Jul
Twenty-six week toxicity study with KASAL® (basic sodium aluminum phosphate) in beagle dogs.
1990 Mar
Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release.
2007 Apr 15
Patents

Patents

04565680
30
05123965
3
05414173
3
06613710
3
US3957679
3
US4166142A
3

Sample Use Guides

In Vivo Use Guide
Rats were fed control diet or diets containing 30,000 ppm KASAL for 28 days. Beagle dogs were fed diets containing up to 30,000 ppm KASAL for 26 weeks.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
KASAL
USAN  
USAN  
Official Name English
SODIUM ALUMINUM PHOSPHATE, BASIC
Common Name English
KASAL [USAN]
Common Name English
PHOSPHORIC ACID, DISODIUM SALT, MIXT. CONTG.
Common Name English
INS NO.541(II)
Common Name English
E-541(II)
Common Name English
KASAL II
Common Name English
BASIC SODIUM ALUMINUM PHOSPHATE
Common Name English
INS-541(II)
Common Name English
Classification Tree Code System Code
JECFA EVALUATION INS-541(II)
Created by admin on Sat Dec 16 08:30:06 GMT 2023 , Edited by admin on Sat Dec 16 08:30:06 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-541(II)
Created by admin on Sat Dec 16 08:30:06 GMT 2023 , Edited by admin on Sat Dec 16 08:30:06 GMT 2023
Code System Code Type Description
PUBCHEM
76971050
Created by admin on Sat Dec 16 08:30:06 GMT 2023 , Edited by admin on Sat Dec 16 08:30:06 GMT 2023
PRIMARY
WIKIPEDIA
SODIUM ALUMINIUM PHOSPHATE
Created by admin on Sat Dec 16 08:30:06 GMT 2023 , Edited by admin on Sat Dec 16 08:30:06 GMT 2023
PRIMARY In addition to the usual hydrate, an anhydrous SAlP is also known, Na3H15Al2(PO4)8 (CAS#10279-59-1), referred to as 8:2:3, reflecting the ratio of phosphate to aluminium to sodium. Additionally an SAlP of ill-defined stoichiometry is used (NaxAly(PO4)z (CAS# 7785-88-8).[3]
NCI_THESAURUS
C170085
Created by admin on Sat Dec 16 08:30:06 GMT 2023 , Edited by admin on Sat Dec 16 08:30:06 GMT 2023
PRIMARY
FDA UNII
F7KUL1KEYI
Created by admin on Sat Dec 16 08:30:06 GMT 2023 , Edited by admin on Sat Dec 16 08:30:06 GMT 2023
PRIMARY
ChEMBL
CHEMBL2108488
Created by admin on Sat Dec 16 08:30:06 GMT 2023 , Edited by admin on Sat Dec 16 08:30:06 GMT 2023
PRIMARY
CAS
110801-42-8
Created by admin on Sat Dec 16 08:30:06 GMT 2023 , Edited by admin on Sat Dec 16 08:30:06 GMT 2023
PRIMARY
SUBSTANCE RECORD
Structure of KASAL
NIH
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