ABANOQUIL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H25N3O4
Molecular Weight	395.4516
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ABANOQUIL

Structure Search

SMILES

COC1=CC2=C(C=C1OC)C(N)=CC(=N2)N3CCC4=CC(OC)=C(OC)C=C4C3

InChI

InChIKey=ANZIISNSHPKVRV-UHFFFAOYSA-N

InChI=1S/C22H25N3O4/c1-26-18-7-13-5-6-25(12-14(13)8-19(18)27-2)22-10-16(23)15-9-20(28-3)21(29-4)11-17(15)24-22/h7-11H,5-6,12H2,1-4H3,(H2,23,24)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10845763

Abanoquil (UK-52,046), an antiarrhythmic drug, is an alpha 1-adrenoceptor antagonist, has been studied for the treatment of erectile dysfunction.

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor alpha-1 171 Target ID: CHEMBL2094251 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10845763	Antagonist 2849

PubMed

PubMed

Title	Date	PubMed
Abanoquil, a new alpha-1 adrenoceptor antagonist. In vitro and in vivo effect on erectile tissue.	2000-03	10845763
Abanoquil, a new alpha-1 adrenoceptor antagonist. In vitro and in vivo effect on erectile tissue.	2000-03	10849564
Dose-dependent alpha 1-adrenoceptor antagonist activity of the anti-arrhythmic drug, abanoquil (UK-52,046), without reduction in blood pressure in man.	1992-04	1349492

Patents

Patents

Sample Use Guides

In Vivo Use Guide

single oral doses of abanoquil 0.25, 0.5 and 1 mg

Route of Administration: Oral

Name

Type

Language

abanoquil [INN]

Preferred Name

English

ABANOQUIL

Official Name

English

4-AMINO-2-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLYL)-6,7-DIMETHOXYQUINOLINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29713

Created by admin on Wed Apr 02 09:39:50 GMT 2025 , Edited by admin on Wed Apr 02 09:39:50 GMT 2025

Code System Code Type Description

WIKIPEDIA

ABANOQUIL

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FDA UNII

F738MWY53L

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INN

6761

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NCI_THESAURUS

C72566

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MESH

C058534

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SMS_ID

100000082323

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PUBCHEM

164089

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ChEMBL

CHEMBL324090

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EPA CompTox

DTXSID40238163

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CAS

90402-40-7

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EVMPD

SUB07358MIG

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ACTIVE MOIETY


					F738MWY53L

ABANOQUIL