Details
Stereochemistry | ACHIRAL |
Molecular Formula | Hf |
Molecular Weight | 178.49 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 4 |
SHOW SMILES / InChI
SMILES
[Hf+4]
InChI
InChIKey=GVOLZAKHRKGRRM-UHFFFAOYSA-N
InChI=1S/Hf/q+4
Hafnium oxide is a radio enhancer; its nanoparticles (NBTXR3) were designed for high dose energy deposition within cancer cells when exposed to ionizing radiation. When activated by radiotherapy (RT), NBTXR3 allows for a higher energy deposit than RT alone, yielding an increased tumoral cell death. Nanocrystals of hafnium oxide are under investigation in phase II/III in patients with locally advanced soft tissue sarcoma (STS) of the extremity and trunk wall. In addition, NBTXR3, nanoparticles are being studied in phase I/II in patients with head and neck cancer; liver cancer; prostate cancer and rectal cancer.
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT02379845
One intratumor implantation by injection of NBTXR3 (Hafnium oxide nanocrystals) + Radiotherapy
Route of Administration:
Other
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admin on Sat Dec 16 14:45:32 GMT 2023 , Edited by admin on Sat Dec 16 14:45:32 GMT 2023
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10154302
Created by
admin on Sat Dec 16 14:45:32 GMT 2023 , Edited by admin on Sat Dec 16 14:45:32 GMT 2023
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SUBSTANCE RECORD