RISEDRONATE SODIUM MONOHYDRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H10NO7P2.Na.H2O
Molecular Weight	323.1094
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of RISEDRONATE SODIUM MONOHYDRATE

Structure Search

SMILES

O.[Na+].OC(CC1=CN=CC=C1)(P(O)(O)=O)P(O)([O-])=O

InChI

InChIKey=KLQNARDFMJRXSF-UHFFFAOYSA-M

InChI=1S/C7H11NO7P2.Na.H2O/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);;1H2/q;+1;/p-1

HIDE SMILES / InChI

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020835s048lbl.pdf
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/mtm/risedronate.html http://www.wikidoc.org/index.php/Risedronate http://www.rxlist.com/actonel-drug.htm

Risedronic acid is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. The action of risedronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Risedronate also targets farnesyl pyrophosphate (FPP) synthase. It is FDA approved for the treatment of postmenopausal osteoporosis, osteoporosis in men, glucocorticoid-induced osteoporosis and Paget’s disease. Calcium, antacids, or oral medications containing divalent cations interfere with the absorption of Risedronic acid. Common adverse reactions include rash, abdominal pain, constipation, diarrhea, indigestion, nausea, backache, urinary tract infectious disease and influenza-like illness.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Hydroxyapatite crystals 4 Target ID: Hydroxyapatite crystals Sources: https://www.ncbi.nlm.nih.gov/pubmed/25568655	Binding Agent 1064
Farnesyl diphosphate synthase 28 Target ID: CHEMBL1782 Sources: http://www.drugbank.ca/drugs/DB00884 \| https://www.ncbi.nlm.nih.gov/pubmed/25568655	Inhibitor 8297		3.9 nM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Postmenopausal osteoporosis 59 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020835s048lbl.pdf	Primary	Approved 8429	ACTONEL Approved Use ACTONEL is indicated for the treatment and prevention of osteoporosis and Paget’s disease of bone in men and women. Launch Date 1998
Glucocorticoid-induced osteoporosis 11 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020835s048lbl.pdf	Primary	Approved 8429	ACTONEL Approved Use ACTONEL is indicated for the treatment and prevention of glucocorticoid-induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoid treatment (daily dosage of ≥ 7.5 mg prednisone or equivalent) for chronic diseases. Launch Date 1998
Paget’s disease of bone 12 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020835s048lbl.pdf	Primary	Approved 8429	ACTONEL Approved Use ACTONEL is indicated for treatment of Paget’s disease of bone in men and women. Launch Date 1998
Increase bone mass in men with osteoporosis 4 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020835s048lbl.pdf	Primary	Approved 8429	ACTONEL Approved Use ACTONEL is indicated for treatment to increase bone mass in men with osteoporosis. Launch Date 1998

C_max

Value	Dose	Co-administered	Analyte	Population
2.05 ng/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/14999521	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:		RISEDRONATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
6.49 ng × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/14999521	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:		RISEDRONATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
1.61 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/14999521	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:		RISEDRONATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

Doses

Dose	Population	Adverse events
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/18038273 Page: p.362	unhealthy, 41.6±15.7 n = 60 Health Status: unhealthy Condition: Glucocorticoid-induced bone mineral density loss prevention Age Group: 41.6±15.7 Sex: M+F Population Size: 60 Sources: https://pubmed.ncbi.nlm.nih.gov/18038273 Page: p.362	Disc. AE: Skin rash, Gastrointestinal upset... AEs leading to discontinuation/dose reduction: Skin rash (1.7%) Gastrointestinal upset (1.7%) Sources: https://pubmed.ncbi.nlm.nih.gov/18038273 Page: p.362
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9	unhealthy, 50 - 86 n = 613 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 613 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9	Disc. AE: Diarrhea... AEs leading to discontinuation/dose reduction: Diarrhea (0.3%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9	unhealthy, 50 - 86 n = 616 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 616 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9	Disc. AE: Vomiting... AEs leading to discontinuation/dose reduction: Vomiting (0.2%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9
75 mg 1 times / day multiple, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: multiple Dose: 75 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9	unhealthy, 50 - 86 n = 616 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 616 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9	Disc. AE: Vomiting, Diarrhea... AEs leading to discontinuation/dose reduction: Vomiting (1%) Diarrhea (1%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9
150 mg 1 times / month multiple, oral Recommended Dose: 150 mg, 1 times / month Route: oral Route: multiple Dose: 150 mg, 1 times / month Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10	unhealthy, 50 - 88 n = 650 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 650 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10	Disc. AE: Abdominal pain upper, Diarrhea... AEs leading to discontinuation/dose reduction: Abdominal pain upper (2.5%) Diarrhea (0.8%) Vomiting (0.3%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10	unhealthy, 50 - 88 n = 642 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 642 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10	Disc. AE: Abdominal pain upper, Vomiting... AEs leading to discontinuation/dose reduction: Abdominal pain upper (1.4%) Vomiting (0.3%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10

AEs

AE	Significance	Dose	Population
Gastrointestinal upset	1.7% Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/18038273 Page: p.362	unhealthy, 41.6±15.7 n = 60 Health Status: unhealthy Condition: Glucocorticoid-induced bone mineral density loss prevention Age Group: 41.6±15.7 Sex: M+F Population Size: 60 Sources: https://pubmed.ncbi.nlm.nih.gov/18038273 Page: p.362
Skin rash	1.7% Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/18038273 Page: p.362	unhealthy, 41.6±15.7 n = 60 Health Status: unhealthy Condition: Glucocorticoid-induced bone mineral density loss prevention Age Group: 41.6±15.7 Sex: M+F Population Size: 60 Sources: https://pubmed.ncbi.nlm.nih.gov/18038273 Page: p.362
Diarrhea	0.3% Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9	unhealthy, 50 - 86 n = 613 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 613 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9
Vomiting	0.2% Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9	unhealthy, 50 - 86 n = 616 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 616 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9
Diarrhea	1% Disc. AE	75 mg 1 times / day multiple, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: multiple Dose: 75 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9	unhealthy, 50 - 86 n = 616 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 616 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9
Vomiting	1% Disc. AE	75 mg 1 times / day multiple, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: multiple Dose: 75 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9	unhealthy, 50 - 86 n = 616 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 616 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.9
Vomiting	0.3% Disc. AE	150 mg 1 times / month multiple, oral Recommended Dose: 150 mg, 1 times / month Route: oral Route: multiple Dose: 150 mg, 1 times / month Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10	unhealthy, 50 - 88 n = 650 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 650 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10
Diarrhea	0.8% Disc. AE	150 mg 1 times / month multiple, oral Recommended Dose: 150 mg, 1 times / month Route: oral Route: multiple Dose: 150 mg, 1 times / month Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10	unhealthy, 50 - 88 n = 650 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 650 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10
Abdominal pain upper	2.5% Disc. AE	150 mg 1 times / month multiple, oral Recommended Dose: 150 mg, 1 times / month Route: oral Route: multiple Dose: 150 mg, 1 times / month Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10	unhealthy, 50 - 88 n = 650 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 650 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10
Vomiting	0.3% Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10	unhealthy, 50 - 88 n = 642 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 642 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10
Abdominal pain upper	1.4% Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10	unhealthy, 50 - 88 n = 642 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 642 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020835s035lbl.pdf Page: p.10

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY510605	https://www.001chemical.com/chem/1197-18-8
3B Scientific (Wuhan) Corp	3B3-004681	http://www.3bsc.com/index/pro_info.php?id=26567
AA Blocks	AA00HAKO	https://www.aablocks.com/goods/Goods/detail?id=AA00HAKO
AHH Chemical co.,ltd	MT-15499	http://www.ahhchemical.com/product/MT-15499.html
AK Scientific, Inc. (AKSCI)	2689AH	http://www.aksci.com/item_detail.php?cat=2689AH
AK Scientific, Inc. (AKSCI)	I802	http://www.aksci.com/item_detail.php?cat=I802
Aaron Chemicals	AR00HBCG	http://www.aaronchem.com/105462-24-6
Acadechem	ACDS-026260	http://www.acadechemical.com/product/100959
Achemo Scientific Limited	AC-15534	http://www.achemo.com/product_view.asp?ID=5424
Achemtek	0104-019190	http://www.achemtek.com/105462-24-6
Adooq BioScience	A11675	https://www.adooq.com/risedronic-acid-actonel.html
Ambeed	A471285	https://www.ambeed.com/products/105462-24-6.html
Angene	AGN-PC-04XTDK	http://www.angenechemical.com/productshow/AGN-PC-04XTDK.html
ApexBio Technology	B1826	http://www.apexbt.com/risedronate.html
AstaTech, Inc.	67956	http://www.astatechinc.com/CPSResult.php?CRNO=14010
Aurum Pharmatech LLC	M-1366	http://www.Aurumpharmatech.com/Product/ProductDetails/M_1366
AvaChem Scientific	2610A	http://www.avachem.com/productSearch.asp?2610A
BLD Pharm	BD17422	http://www.bldpharm.com/products/105462-24-6.html
BioChemPartner	BCP13805	http://www.biochempartner.com/105462-24-6-BCP13805
BioCrick	BCC4711	http://www.biocrick.com/Risedronate-BCC4711.html
Boerchem	BC206977	http://www.boerchem.com/?product_34916.html
CSNpharm	CSN12477	https://www.csnpharm.com/products/risedronate.html
Capot Chemical	14002	http://www.capotchem.com/en/14002.htm
Capot Chemical	PubChem14002	http://www.capotchem.com/en/14002.htm
Chem Scene	CS-1964	http://www.chemscene.com/105462-24-6.html
ChemMol	30103518	http://www.chemmol.com/chemmol/30103518.html
ChemMol	44002664	http://www.chemmol.com/chemmol/44002664.html
ChemMol	49408876	http://www.chemmol.com/chemmol/49408876.html
Chemenu	CM110535	http://www.chemenu.com/products/CM110535
Chemspace	CSSB00000692965	https://chem-space.com/CSSB00000692965
Clearsynth	CS-O-11736	https://www.clearsynth.com/en/CSO11736.html
DC Chemicals	DCAPI1012	http://www.dcchemicals.com//product_show-Risedronic_acid_Actonel_.html
Enamine	Z2684418685	https://www.enaminestore.com/catalog/Z2684418685
Finetech	FT-0642593	http://www.finetechnology-ind.com/prod/detail/pub/105462-24-6.html
Glentham Life Sciences	GP6400	http://www.glentham.com/products/product/GP6400/
Hairui	HR124405	http://www.hairuichem.com/en/product/1197-18-8.html
Huateng Pharma	F80017483	http://en.huatengsci.com/product/Risedronic-acid-monohydrate.html
LGC Standards	MM0777.09-0025	https://www.lgcstandards.com/US/en/p/MM0777.09-0025
MedChem Express	HY-B0148	https://www.medchemexpress.com/Risedronic-acid.html
Molcore	MC510605	https://www.molcore.com/product/1197-18-8
MuseChem	A000751	https://www.musechem.com/product/A000751.html
OChem	3875	http://www.ocheminc.com/index.php?act=psearch&pid=462R246
Selleck Chemicals	S1874	http://www.selleckchem.com/products/risedronic-acid-actonel.html
Sinfoo Biotech	S010603	http://www.sinfoobiotech.com/product/1014001
Smolecule	S591430	https://www.smolecule.com/products/s591430
THE BioTek	bt-311863	https://www.thebiotek.com/product/others/bt-311863
Yuhao Chemical	XJ6805	http://www.chemyuhao.com/105462-24-6.html
abcr GmbH	AB504521	http://www.abcr.com/shop/en/AB504521

PubMed

Title	Date	PubMed
Osteoporosis in children and adolescent girls: case report of idiopathic juvenile osteoporosis and review of the literature.	2001 Aug	11496161
Risedronate for the prevention and treatment of postmenopausal osteoporosis: results from recent clinical trials.	2001 Dec	11846337
Risedronate pharmacokinetics and intra- and inter-subject variability upon single-dose intravenous and oral administration.	2001 Feb	11405286
Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation.	2001 Feb	11160853
Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group.	2001 Feb 1	11172164
Risedronate: a clinical review.	2001 Feb 12	11176760
Effect of high doses of oral risedronate (20 mg/day) on serum parathyroid hormone levels and urinary collagen cross-link excretion in postmenopausal women with spinal osteoporosis.	2001 Jan	11165950
(31)P NMR of apicomplexans and the effects of risedronate on Cryptosporidium parvum growth.	2001 Jun 15	11396947
Evidence-based medicine: putting theory into practice.	2001 Mar	11291467
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.	2001 Mar 15	11300872
The effect of risedronate on the risk of hip fracture in elderly women.	2001 May 31	11386284
The effect of risedronate on the risk of hip fracture in elderly women.	2001 May 31	11386283
The effect of risedronate on the risk of hip fracture in elderly women.	2001 May 31	11386282
Role of alendronate and risedronate in preventing and treating osteoporosis.	2001 Nov	11718433
A method to assess the proportion of treatment effect explained by a surrogate endpoint.	2001 Nov 15	11746311
Alendronate for the treatment of osteoporosis in men.	2001 Oct	11730259
Maintenance of cancellous bone in ovariectomized, human parathyroid hormone [hPTH(1-84)]-treated rats by estrogen, risedronate, or reduced hPTH.	2001 Oct	11595618
Bisphosphonates for osteoporosis.	2001 Sep	11586803
Vgamma2Vdelta2 T-cell receptor-mediated recognition of aminobisphosphonates.	2001 Sep 1	11520816
Direct effects of bisphosphonates on breast cancer cells.	2002	11879555
[When osteoporosis first manifests itself. Without therapy the next fracture threatens].	2002 Apr 4	12014286
The efficacy and tolerability of risedronate once a week for the treatment of postmenopausal osteoporosis.	2002 Aug	12085156
Risedronate preserves trabecular architecture and increases bone strength in vertebra of ovariectomized minipigs as measured by three-dimensional microcomputed tomography.	2002 Jul	12096826
Activity of bisphosphonates against Trypanosoma brucei rhodesiense.	2002 Jul 4	12086478
Treatment of postmenopausal osteoporosis.	2002 Jun 8	12076571
Gateways to clinical trials.	2002 May	12092009
Risedronate: a new oral bisphosphonate.	2002 May	12075950
The potential of parathyroid hormone as a therapy for osteoporosis.	2002 May-Jun	12081255

Patents

Sample Use Guides

In Vivo Use Guide

Treatment of Postmenopausal Osteoporosis: 5 mg daily, 35 mg once-a-week, 75 mg two consecutive days each month, 150 mg once-a-month. Prevention of Postmenopausal Osteoporosis: 5 mg daily, 35 mg once-a-week. Men with Osteoporosis: 35 mg once-a-week. Glucocorticoid-Induced Osteoporosis: 5 mg daily. Paget’s Disease: 30 mg daily for 2 month.

Route of Administration: Oral

In Vitro Use Guide

The antimalarial activities of risedronate, one of the most potent bisphosphonates clinically used to treat bone resorption diseases, against blood stages of Plasmodium falciparum (50% inhibitory concentration [IC50] of 20.3±1.0 μM).

Name

Type

Language

RISEDRONATE SODIUM MONOHYDRATE

Common Name

English

RISEDRONIC ACID MONOSODIUM SALT MONOHYDRATE

Common Name

English

PHOSPHONIC ACID, P,P'-(1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE)BIS-, SODIUM SALT, HYDRATE (1:1:1)

Common Name

English

Risedronate sodium monohydrate [WHO-DD]

Common Name

English

Code System Code Type Description

PUBCHEM

23709605