Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C9H10N4O3S2 |
| Molecular Weight | 286.331 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=NSN=C1NS(=O)(=O)C2=CC=C(N)C=C2
InChI
InChIKey=IZOYMGQQVNAMHS-UHFFFAOYSA-N
InChI=1S/C9H10N4O3S2/c1-16-9-8(11-17-12-9)13-18(14,15)7-4-2-6(10)3-5-7/h2-5H,10H2,1H3,(H,11,13)
Sulfametrole is a sulfonamide antibiotic used typically in combination with trimethoprim. Sulfametrole combined with trimethoprim could provide a choice for difficult-to-treat infections, particularly when administered intravenously. Sulfametrole/trimethoprim is an alternative sulphonamide/trimethoprim combination available in several EU countries, including Austria and the Netherlands. Sulphonamide/trimethoprim combination is the most active antibacterial but sulfametrole and sulfametrole/trimethoprim did not overcome resistance to sulfamethoxazole and sulfamethoxazole/trimethoprim in Enterobacteriaceae.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Order-disorder enantiotropy, monotropy, and isostructurality in a tetroxoprim-sulfametrole 1:1 molecular complex: Crystallographic and thermal studies. | 2003 Nov |
|
| Synthesis, spectroscopic, thermal and antimicrobial studies of some novel metal complexes of Schiff base derived from [N1-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfanilamide] and 2-thiophene carboxaldehyde. | 2007 Apr |
|
| Metal complexes of Schiff base derived from sulphametrole and o-vanilin. Synthesis, spectral, thermal characterization and biological activity. | 2007 Apr |
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WHO-ATC |
J01EE03
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NCI_THESAURUS |
C29739
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SULFAMETROLE
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100000083272
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DTXSID40865655
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251-288-1
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64939
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37328
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C72852
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3526
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CHEMBL2105398
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32909-92-5
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SUB10715MIG
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F5AK41IPQG
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2518
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m10322
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PRIMARY | Merck Index |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
