| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H15NO4 |
| Molecular Weight | 237.2518 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC1=C(C=CC(NC(C)=O)=C1)C(=O)OC
InChI
InChIKey=GOVWOKSKFSBNGD-UHFFFAOYSA-N
InChI=1S/C12H15NO4/c1-4-17-11-7-9(13-8(2)14)5-6-10(11)12(15)16-3/h5-7H,4H2,1-3H3,(H,13,14)
Ethopabate is a veterinary drug used in the prophylaxis and treatment of coccidiosis in chickens. It is an arylamide containing one phenyl ring, belonging to monocyclic aromatics, is a very safe drug. It has anticoccidial activity especially against intestinal forms and lacks activity against E. tenella of caecal worms. This drug is a competitor of PABA for absorption by the parasite and interferes with folate synthesis. It has good activity against E. acervulina and some strains of E. maxima and E. brunette. It has been used only in combination with Amprolium first at 4 ppm and later at 40 ppm. This drug has peak activity on 4th day of cycle. Ethopabate is a component of marketed AMPROL PLUS (amprolium, ethopabate), indicated for use as an aid in the prevention of coccidiosis (1) in broiler chickens and (2) in replacement chickens where immunity to coccidiosis is not desired.
Originator
Approval Year
PubMed
Patents
Sample Use Guides
AMPROL PLUS (amprolium, ethopabate) should be thoroughly and evenly mixed in the feed. AMPROL PLUS may be used
to manufacture a Type C medicated feed in the concentration range of 0.0125% - 0.025% amprolium and 0.0004% ethopabate.
One pound of AMPROL PLUS should be mixed with one ton of non-medicated feed to produce a Type C medicated
feed containing 0.0125% amprolium / 0.0004% ethopabate. One pound of AMPROL PLUS and one pound of AMPROL
(amprolium) 25% mixed with one ton of non-medicated feed will produce a feed containing 0.025% amprolium and
0.0004% ethopabate.
Route of Administration:
Oral
The short-term toxicity (EC50 respectively LC50 after 2 or 4 days) of 13 feed additives was determined to 4 freshwater organisms of different trophical levels: Chlorella pyrenoidosa, Daphnia magna, Lebistes reticulatus and Salmo gairdneri. ethopabate, furazolidone and zoalene proved to be little toxic (LC(EC)50 greater than 10 mg/1).
ACTIVE MOIETY
