Details
Stereochemistry | ACHIRAL |
Molecular Formula | C24H28N4O4 |
Molecular Weight | 436.5035 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(=CC=C1)C(=O)NC2=CC=C(OCCN3CCOCC3)C(=C2)C4=CC=NN4C
InChI
InChIKey=ZEOQUKRCASTCFR-UHFFFAOYSA-N
InChI=1S/C24H28N4O4/c1-27-22(8-9-25-27)21-17-19(26-24(29)18-4-3-5-20(16-18)30-2)6-7-23(21)32-15-12-28-10-13-31-14-11-28/h3-9,16-17H,10-15H2,1-2H3,(H,26,29)
Temanogrel (also known as APD791) is an oral small molecule inverse agonist of the serotonin 2A (5-HT2A) receptor with potent activity on platelets and vascular smooth muscle. Temanogrel has been studied in phase I clinical trials in healthy subjects to assess its pharmacokinetics, pharmacodynamics, and safety. However, these studies were terminated because of the sponsor’s decision.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL224 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19628629 |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT02419820
APD791 (temanogrel) (10 or 20 or 40) mg single dose
Route of Administration:
Oral
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NCI_THESAURUS |
C66885
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)