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Details

Stereochemistry ACHIRAL
Molecular Formula C21H28N2O8S2
Molecular Weight 500.586
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SB-756050

SMILES

COC1=C(OC)C=C(C=C1)S(=O)(=O)N2CCCN(CC2)S(=O)(=O)C3=CC(OC)=C(OC)C=C3

InChI

InChIKey=GJUFPAZNBPFNRI-UHFFFAOYSA-N
InChI=1S/C21H28N2O8S2/c1-28-18-8-6-16(14-20(18)30-3)32(24,25)22-10-5-11-23(13-12-22)33(26,27)17-7-9-19(29-2)21(15-17)31-4/h6-9,14-15H,5,10-13H2,1-4H3

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q8TDU6
Gene ID: 151306.0
Gene Symbol: GPBAR1
Target Organism: Homo sapiens (Human)
Name Type Language
SB-756050
Common Name English
1H-1,4-DIAZEPINE, 1,4-BIS((3,4-DIMETHOXYPHENYL)SULFONYL)HEXAHYDRO-
Systematic Name English
SB-050
Code English
1,4-BIS((3,4-DIMETHOXYPHENYL)SULFONYL)-1,4-DIAZEPANE
Systematic Name English
Code System Code Type Description
FDA UNII
F3EST236LD
Created by admin on Sat Dec 16 11:36:41 GMT 2023 , Edited by admin on Sat Dec 16 11:36:41 GMT 2023
PRIMARY
EPA CompTox
DTXSID201025986
Created by admin on Sat Dec 16 11:36:41 GMT 2023 , Edited by admin on Sat Dec 16 11:36:41 GMT 2023
PRIMARY
PUBCHEM
1520267
Created by admin on Sat Dec 16 11:36:41 GMT 2023 , Edited by admin on Sat Dec 16 11:36:41 GMT 2023
PRIMARY
CAS
447410-57-3
Created by admin on Sat Dec 16 11:36:41 GMT 2023 , Edited by admin on Sat Dec 16 11:36:41 GMT 2023
PRIMARY
CLINICAL_TRIALS.GOV
SB-756050
Created by admin on Sat Dec 16 11:36:41 GMT 2023 , Edited by admin on Sat Dec 16 11:36:41 GMT 2023
PRIMARY A Single-blinded Randomized, Placebo-controlled, Staggered-parallel, Escalating-dose Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral SB756050 Administered for 6 Days to Subjects With Type 2 Diabetes Mellitus Purpose: This is an escalating dose study in subjects with T2DM, which will consist of four overlapping cohorts receiving 6 days of SB756050 to assess safety, pharmacokinetics, and pharmacodynamics.