MINOCROMIL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H16N2O6
Molecular Weight	356.3294
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MINOCROMIL

Structure Search

SMILES

CCCC1=C2OC(=CC(=O)C2=CC3=C1N=C(C=C3NC)C(O)=O)C(O)=O

InChI

InChIKey=RMPRGCBYQSAAAZ-UHFFFAOYSA-N

InChI=1S/C18H16N2O6/c1-3-4-8-15-9(11(19-2)6-12(20-15)17(22)23)5-10-13(21)7-14(18(24)25)26-16(8)10/h5-7H,3-4H2,1-2H3,(H,19,20)(H,22,23)(H,24,25)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2999403 | https://adisinsight.springer.com/drugs/800000076

Minocromil was studied as a histamine receptor antagonist for the treatment of asthma. However, further development of the drug was discontinued.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
Protective effect of a new anti-asthmatic agent (Minocromil) in bronchial allergen challenge tests.	1985 Aug	4051146
New antiallergic pyrano [3,2-g]quinoline-2,8-dicarboxylic acids with potential for the topical treatment of asthma.	1985 Dec	2999403
Attenuation of exercise-induced asthma by pretreatment with nedocromil sodium and minocromil.	1985 Jul	2992839

Name

Type

Language

MINOCROMIL

Official Name

English

4H-PYRANO(3,2-G)QUINOLINE-2,8-DICARBOXYLIC ACID, 6-(METHYLAMINO)-4-OXO-10-PROPYL-

Common Name

English

FPL-59360

Code

English

FPL 59360

Code

English

6-(Methylamino)-4-oxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid

Systematic Name

English

MINOCROMIL [USAN]

Common Name

English

MINOCROMIL [MART.]

Common Name

English

minocromil [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578

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Code System Code Type Description

ChEMBL

CHEMBL1207579

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INN

5419

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FDA UNII

F37A9VKY5Q

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NCI_THESAURUS

C66162

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SMS_ID

100000080660

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CAS

85118-44-1

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USAN

W-100

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EVMPD

SUB08979MIG

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PUBCHEM

71448

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EPA CompTox

DTXSID30234255

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MESH

C046324

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ACTIVE MOIETY


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