Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C26H21FN2O3 |
| Molecular Weight | 428.4549 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@H](N(CC1=CC(=CC=C1)C(O)=O)C(=O)C2=CC3=CC=CC=C3N=C2)C4=CC=C(F)C=C4
InChI
InChIKey=BXNMZRPTQFVRFA-QGZVFWFLSA-N
InChI=1S/C26H21FN2O3/c1-17(19-9-11-23(27)12-10-19)29(16-18-5-4-7-21(13-18)26(31)32)25(30)22-14-20-6-2-3-8-24(20)28-15-22/h2-15,17H,16H2,1H3,(H,31,32)/t17-/m1/s1
Approval Year
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
1398583-31-7
Created by
admin on Sat Dec 16 12:01:45 GMT 2023 , Edited by admin on Sat Dec 16 12:01:45 GMT 2023
|
PRIMARY | |||
|
DTXSID301336742
Created by
admin on Sat Dec 16 12:01:45 GMT 2023 , Edited by admin on Sat Dec 16 12:01:45 GMT 2023
|
PRIMARY | |||
|
DB15450
Created by
admin on Sat Dec 16 12:01:45 GMT 2023 , Edited by admin on Sat Dec 16 12:01:45 GMT 2023
|
PRIMARY | |||
|
F2B10OFV7Y
Created by
admin on Sat Dec 16 12:01:45 GMT 2023 , Edited by admin on Sat Dec 16 12:01:45 GMT 2023
|
PRIMARY | |||
|
60195662
Created by
admin on Sat Dec 16 12:01:45 GMT 2023 , Edited by admin on Sat Dec 16 12:01:45 GMT 2023
|
PRIMARY | |||
|
PF-05105679
Created by
admin on Sat Dec 16 12:01:45 GMT 2023 , Edited by admin on Sat Dec 16 12:01:45 GMT 2023
|
PRIMARY | Description: TRPM8 inhibitor (IC50 value 0.1 .MU.M for TRPM8 in single cell patch clamp electrophysiology (Ephys) studies), showing >100-fold selectivity across a range of different receptors, ion channels, and enzymes including the closely related TRPV1 and TRPA1 channels. Although PF-05105679 shows no effect on core body temperature in humans, it proofs to be a useful tool to study in vitro effects of TRPM8 on thermoregulation and for the treatment of pain in humans. | ||
|
PF-05105679
Created by
admin on Sat Dec 16 12:01:45 GMT 2023 , Edited by admin on Sat Dec 16 12:01:45 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
