MAVATREP

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H21F3N2O
Molecular Weight	422.4422
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(O)C1=CC=CC=C1C2=CC=C3N=C(NC3=C2)\C=C\C4=CC=C(C=C4)C(F)(F)F

InChI

InChIKey=ORDHXXHTBUZRCN-NTEUORMPSA-N

InChI=1S/C25H21F3N2O/c1-24(2,31)20-6-4-3-5-19(20)17-10-13-21-22(15-17)30-23(29-21)14-9-16-7-11-18(12-8-16)25(26,27)28/h3-15,31H,1-2H3,(H,29,30)/b14-9+

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25850459 | https://www.ncbi.nlm.nih.gov/pubmed/29794306

Mavatrep (JNJ-39439335) is a TRPV1 antagonist. It exerts analgesic potential. Mavatrep demonstrated sustained pharmacodynamic effects (heat pain perception, heat pain latency, capsaicin-induced flare), and an efficacy signal in participants with osteoarthritis

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Transient receptor potential cation channel subfamily V member 1 6 Target ID: Q8NER1 Gene ID: 7442.0 Gene Symbol: TRPV1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/25850459	Antagonist 2778		4.6 nM [IC50]

PubMed

Title	Date	PubMed
Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep).	2015 May 14	25850459
A multiple-dose double-blind randomized study to evaluate the safety, pharmacokinetics, pharmacodynamics and analgesic efficacy of the TRPV1 antagonist JNJ-39439335 (mavatrep).	2018 Apr 25	29794306

Patents

Name

Type

Language

MAVATREP

Official Name

English

JNJ-39439335

Code

English

MAVATREP [MI]

Common Name

English

mavatrep [INN]

Common Name

English

(E)-2-(2-(2-(2-(4-TRIFLOUROMETHYL-PHENYL)-VINYL)-1H-BENZIMIDAZOL-5-YL)-PHENYL)-PROPAN-2-OL

Common Name

English

MAVATREP [USAN]

Common Name

English

BENZENEMETHANOL, .ALPHA.,.ALPHA.-DIMETHYL-2-(2-((1E)-2-(4-(TRIFLUOROMETHYL)PHENYL)ETHENYL)-1H-BENZIMIDAZOL-6-YL)-

Systematic Name

English

Mavatrep [WHO-DD]

Common Name

English

Code System Code Type Description

FDA UNII

F197218T99