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Details

Stereochemistry ACHIRAL
Molecular Formula C14H18NO
Molecular Weight 216.2988
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of QUINUCLIUM

SMILES

C[N+]12CCC(CC1)(C(=O)C2)C3=CC=CC=C3

InChI

InChIKey=UCKSYFRXTAWSPV-UHFFFAOYSA-N
InChI=1S/C14H18NO/c1-15-9-7-14(8-10-15,13(16)11-15)12-5-3-2-4-6-12/h2-6H,7-11H2,1H3/q+1

HIDE SMILES / InChI
Quinuclium Bromide Anhydrous is quinuclidinium derivative with potential analgesic activity. In preclinical studies, Quinuclium possessed significant chronic antihypertensive activity in mecamylamine- and renal-hypertensive dogs. Quinuclium was approximately 4 times more potent than guanethidine in the former model and 3 times as potent in the latter. Quinuclium reduced orthostatic blood pressure responses in unanesthetized rabbits but was approximately 10 times less potent than guanethidine. Quinuclium did not affect cardiac output, heart rate or stroke volume in anesthetized open-chest dogs and moderately increased mean blood pressure and total peripheral resistance. It produced diuresis and saluresis in anesthetized dogs but did not influence water or electrolyte urinary excretion in conscious rats. Quinuclium was more effective than guanethidine in blocking adrenergic neurons and depleting heart norepinephrine levels in experimental animals.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Patents

Name Type Language
QUINUCLIUM
Common Name English
1-METHYL-3-OXO-4-PHENYLQUINUCLIDINIUM
Systematic Name English
1-AZONIABICYCLO(2.2.2)OCTANE, 1-METHYL-3-OXO-4-PHENYL-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C270
Created by admin on Fri Dec 15 16:10:39 GMT 2023 , Edited by admin on Fri Dec 15 16:10:39 GMT 2023
Code System Code Type Description
MESH
C013356
Created by admin on Fri Dec 15 16:10:39 GMT 2023 , Edited by admin on Fri Dec 15 16:10:39 GMT 2023
PRIMARY
FDA UNII
F06X2L7LQN
Created by admin on Fri Dec 15 16:10:39 GMT 2023 , Edited by admin on Fri Dec 15 16:10:39 GMT 2023
PRIMARY
CAS
740741-60-0
Created by admin on Fri Dec 15 16:10:39 GMT 2023 , Edited by admin on Fri Dec 15 16:10:39 GMT 2023
PRIMARY
PUBCHEM
47459
Created by admin on Fri Dec 15 16:10:39 GMT 2023 , Edited by admin on Fri Dec 15 16:10:39 GMT 2023
PRIMARY
NCI_THESAURUS
C87631
Created by admin on Fri Dec 15 16:10:39 GMT 2023 , Edited by admin on Fri Dec 15 16:10:39 GMT 2023
PRIMARY
EPA CompTox
DTXSID00224981
Created by admin on Fri Dec 15 16:10:39 GMT 2023 , Edited by admin on Fri Dec 15 16:10:39 GMT 2023
PRIMARY