Nuvisertib

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H25F3N4O
Molecular Weight	418.4553
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(O)[C@H]1CC[C@@H](CC1)NC2=NN3C(C=C2)=NC=C3C4=CC=CC(=C4)C(F)(F)F

InChI

InChIKey=XRNVABDYQLHODA-JCNLHEQBSA-N

InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serine/threonine-protein kinase PIM1 13 Target ID: CHEMBL2147 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24953177	Inhibitor 8504		5.0 nM [Ki]
Serine/threonine-protein kinase PIM3 10 Target ID: CHEMBL5407 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24953177	Inhibitor 8504		42.0 nM [Ki]

Name

Type

Language

Nuvisertib

Official Name

English

TP-3654

Preferred Name

English

4-((3-(3-(TRIFLUOROMETHYL)PHENYL)IMIDAZO(1,2-B)PYRIDAZIN-6-YL)AMINO) -TRANS-CYCLOHEXYL)PROPAN-2-OL

Systematic Name

English

trans-?,?-Dimethyl-4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]cyclohexanemethanol

Systematic Name

English

SGI-9481

Code

English

Cyclohexanemethanol, ?,?-dimethyl-4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]-, trans-

Common Name

English

TP3654

Code

English

SGI9481

Code

English

nuvisertib [INN]

Common Name

English

Code System Code Type Description

FDA UNII

EOB0N7BOY4