BENZILONIUM BROMIDE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H28NO3.Br
Molecular Weight	434.367
Optical Activity	( + / - )
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

[Br-].CC[N+]1(CC)CCC(C1)OC(=O)C(O)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=GGMMWVHTLAENAS-UHFFFAOYSA-M

InChI=1S/C22H28NO3.BrH/c1-3-23(4-2)16-15-20(17-23)26-21(24)22(25,18-11-7-5-8-12-18)19-13-9-6-10-14-19;/h5-14,20,25H,3-4,15-17H2,1-2H3;1H/q+1;/p-1

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Description

Benzilonium is an antispasmodic and antimuscarinic drug. Benzilonium bromide is a quarternary antimuscarinic agent with minimal passage of the blood-brain barrier.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 162	Antagonist 2,849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Duodenal ulcer 49	Primary		Approved 8,583	Ulcoban

Doses

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Dose	Population	Adverse events
30 mg single, intravenous Highest studied dose	unhealthy, ADULT	Other AEs: Shock...
35 mg 2 times / day multiple, oral Highest studied dose	healthy, ADULT

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AEs

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AE	Significance	Dose	Population
Shock	grade 2, 13%	30 mg single, intravenous Highest studied dose	unhealthy, ADULT

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PubMed

Title	Date	PubMed
No data available in table

Patents

Sample Use Guides

In Vivo Use Guide

Intravenous injection of benzilonium bromide in a dose close to 70 ug/kg, and atropine in the low dose of 30 ug/kg inhibited the acid response to sham feeding by about 65%.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Show entries

Name

Type

Language

BENZILONIUM BROMIDE

Official Name

English

MINELCIN

Preferred Name

English

BENZILONE BROMIDE

Common Name

English

3-BENZILOYLOXY-1,1-DIETHYLPYRROLIDINIUM BROMIDE

Systematic Name

English

CN-20,172-3

Code

English

Showing 1 to 5 of 24 entries

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Classification Tree

Code System

Code

Anticholinergic Agent

NCI_THESAURUS

C29704

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Code System

Code

Type

Description

MERCK INDEX

m581

PRIMARY

Merck Index

NSC

107530

PRIMARY

CAS

1050-48-2

PRIMARY

NCI_THESAURUS

C72943

PRIMARY

SMS_ID

100000086384

PRIMARY

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ACTIVE MOIETY


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BENZILONIUM

SUBSTANCE RECORD


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BENZILONIUM BROMIDE