Details
Stereochemistry | RACEMIC |
Molecular Formula | C17H12Cl3N3O |
Molecular Weight | 380.656 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=C(C=C1)[C@@]3(CN2C=NC=N2)O[C@@H]3C4=C(Cl)C=C(Cl)C=C4
InChI
InChIKey=HUSJLAKLJPOCEL-IAGOWNOFSA-N
InChI=1S/C17H12Cl3N3O/c18-12-3-1-11(2-4-12)17(8-23-10-21-9-22-23)16(24-17)14-6-5-13(19)7-15(14)20/h1-7,9-10,16H,8H2/t16-,17-/m1/s1
Alteconazole is a triazole that was under development by Knoll Pharmaceuticals as both an orally and topically active antifungal drug. MICs were reported against Microsporum ferruginium, C. albicans, and Mucor pusilis. In mice, alteconazole administered orally produced greater antifungal activity than the reference compounds assayed. In a rat model of experimental vaginal candidiasis, alteconazole was active following both oral and topical administration. Alteconazole developed for the treatment of superficial mycoses, dermatomycoses, and systemic mycoses.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3069196
Curator's Comment: Mice data
Administered for 4 days at 100 mg/kg
Route of Administration:
Oral
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C514
Created by
admin on Fri Dec 15 16:34:39 GMT 2023 , Edited by admin on Fri Dec 15 16:34:39 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
93479-96-0
Created by
admin on Fri Dec 15 16:34:39 GMT 2023 , Edited by admin on Fri Dec 15 16:34:39 GMT 2023
|
PRIMARY | |||
|
100000087475
Created by
admin on Fri Dec 15 16:34:39 GMT 2023 , Edited by admin on Fri Dec 15 16:34:39 GMT 2023
|
PRIMARY | |||
|
DTXSID301024767
Created by
admin on Fri Dec 15 16:34:39 GMT 2023 , Edited by admin on Fri Dec 15 16:34:39 GMT 2023
|
PRIMARY | |||
|
CHEMBL2104617
Created by
admin on Fri Dec 15 16:34:39 GMT 2023 , Edited by admin on Fri Dec 15 16:34:39 GMT 2023
|
PRIMARY | |||
|
C78031
Created by
admin on Fri Dec 15 16:34:39 GMT 2023 , Edited by admin on Fri Dec 15 16:34:39 GMT 2023
|
PRIMARY | |||
|
5725
Created by
admin on Fri Dec 15 16:34:39 GMT 2023 , Edited by admin on Fri Dec 15 16:34:39 GMT 2023
|
PRIMARY | |||
|
SUB05377MIG
Created by
admin on Fri Dec 15 16:34:39 GMT 2023 , Edited by admin on Fri Dec 15 16:34:39 GMT 2023
|
PRIMARY | |||
|
EA590X615B
Created by
admin on Fri Dec 15 16:34:39 GMT 2023 , Edited by admin on Fri Dec 15 16:34:39 GMT 2023
|
PRIMARY | |||
|
172289
Created by
admin on Fri Dec 15 16:34:39 GMT 2023 , Edited by admin on Fri Dec 15 16:34:39 GMT 2023
|
PRIMARY |
ACTIVE MOIETY