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Details

Stereochemistry ACHIRAL
Molecular Formula In
Molecular Weight 110.9051
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of INDIUM IN-111

SMILES

[111In]

InChI

InChIKey=CXQHBGCUHODCNP-RKJSAQOFSA-N
InChI=1S/In.3H/i1-4;;;

HIDE SMILES / InChI
Indium In-111 is used in specialized diagnostic applications, for example, with indium-111 labelled antibodies. It is useful for labelling blood cell components. Other applications include labelling of platelets for thrombus detection, labelled leukocytes for localization of inflammation and abscesses, as well as leukocyte kinetics. Indium forms a saturated (1:3) complex with oxyquinoline. The complex is neutral and lipidsoluble, which enables it to penetrate the cell membrane. Within the cell, indium becomes firmly attached to cytoplasmic components; the liberated oxyquinoline is released by the cell. It is thought likely that the mechanism of labeling cells with indium In 111 oxyquinoline involves an exchange reaction between the oxyquinoline carrier and subcellular components which chelate indium more strongly than oxyquinoline. Indium In-111 oxyquinoline is indicated for radiolabeling autologous leukocytes. Indium In-111 oxyquinoline labeled leukocytes may be used as an adjunct in the detection of inflammatory processes to which leukocytes migrate, such as those associated with abscesses or other infection, following reinjection and detection by appropriate imaging procedures. The degree of accuracy may vary with labeling techniques and with the size, location and nature of the inflammatory process. Sensitivity reactions (urticaria) have been reported. The presence of fever may mask pyrogenic reactions from indium In 111 oxyquinoline labeled leukocytes. Indium In-111 Chloride is a diagnostic radiopharmaceutical intended for radiolabeling OncoScint (satumomab pendetide) or ProstaScint (capromab pendetide) used for in vivo diagnostic imaging procedures and for radiolabeling Zevalin (ibritumomab tiuxetan) in preparations used for radioimmunotherapy procedures.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
INDIUM IN-111 CHLORIDE

Approved Use

Indium In 111 Chloride Sterile Solution is indicated for radiolabeling OncoScint CR/OV or ProstaScint preparations used for in vivo diagnostic imaging procedures. It is also indicated for radiolabeling Zevalin preparations used for Radioimmunotherapy procedures.

Launch Date

1994

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Imaging is recommended at approximately 24 hours post injection.
The recommended adult (70 kg) dose of indium In 111 oxyquinoline labeled autologous leukocytes is 7.4 to 18.5 MBq, 200-500 µCi. Indium In 111 oxyquinoline solution is intended for the radiolabeling of autologous leukocytes.
Route of Administration: Intravenous
Name Type Language
INDIUM IN-111
Common Name English
INDIUM (111 IN)
WHO-DD  
Common Name English
INDIUM, ISOTOPE OF MASS 111
Common Name English
Indium (111 in) [WHO-DD]
Common Name English
INDIUM-111
Common Name English
INDIUM (111IN)
Common Name English
111IN
Common Name English
INDIUM, IN-111
Common Name English
ISOTOPE OF MASS 111
Common Name English
INDIUM IN 111
VANDF  
Common Name English
INDIUM IN 111 [VANDF]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C799
Created by admin on Fri Dec 15 21:31:12 GMT 2023 , Edited by admin on Fri Dec 15 21:31:12 GMT 2023
Code System Code Type Description
DRUG BANK
DB11916
Created by admin on Fri Dec 15 21:31:12 GMT 2023 , Edited by admin on Fri Dec 15 21:31:12 GMT 2023
PRIMARY
CAS
15750-15-9
Created by admin on Fri Dec 15 21:31:12 GMT 2023 , Edited by admin on Fri Dec 15 21:31:12 GMT 2023
PRIMARY
NCI_THESAURUS
C1640
Created by admin on Fri Dec 15 21:31:12 GMT 2023 , Edited by admin on Fri Dec 15 21:31:12 GMT 2023
PRIMARY
EVMPD
SUB14202MIG
Created by admin on Fri Dec 15 21:31:12 GMT 2023 , Edited by admin on Fri Dec 15 21:31:12 GMT 2023
PRIMARY
RXCUI
90540
Created by admin on Fri Dec 15 21:31:12 GMT 2023 , Edited by admin on Fri Dec 15 21:31:12 GMT 2023
PRIMARY RxNorm
CAS
454695-43-3
Created by admin on Fri Dec 15 21:31:12 GMT 2023 , Edited by admin on Fri Dec 15 21:31:12 GMT 2023
ALTERNATIVE
SMS_ID
100000090535
Created by admin on Fri Dec 15 21:31:12 GMT 2023 , Edited by admin on Fri Dec 15 21:31:12 GMT 2023
PRIMARY
PUBCHEM
5462099
Created by admin on Fri Dec 15 21:31:12 GMT 2023 , Edited by admin on Fri Dec 15 21:31:12 GMT 2023
PRIMARY
FDA UNII
E9NGC49E0T
Created by admin on Fri Dec 15 21:31:12 GMT 2023 , Edited by admin on Fri Dec 15 21:31:12 GMT 2023
PRIMARY
EPA CompTox
DTXSID001019286
Created by admin on Fri Dec 15 21:31:12 GMT 2023 , Edited by admin on Fri Dec 15 21:31:12 GMT 2023
PRIMARY