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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H13NO3.C4H11NO3
Molecular Weight 376.4037
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of KETOROLAC TROMETHAMINE, (S)-

SMILES

NC(CO)(CO)CO.OC(=O)[C@H]1CCN2C1=CC=C2C(=O)C3=CC=CC=C3

InChI

InChIKey=BWHLPLXXIDYSNW-MERQFXBCSA-N
InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2/t11-;/m0./s1

HIDE SMILES / InChI
(S)-ketorolac is the enantiomer of ketorolac, a nonsteroidal anti-inflammatory drug. (S)-ketorolac exhibited potent cyclooxygenase (COX1 and COX2) enzyme inhibition. (S)-ketorolac is considered to be active enantiomer of racemic ketorolac.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.46 µM [IC50]
1.46 µM [IC50]
Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac.
1986 Apr
Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen.
1999 Feb 15
Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats.
1999 Jul
Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat.
1999 Mar
Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics.
2017 Sep

Sample Use Guides

rats: 0.01–1 mg/kg s.c.
Route of Administration: Other
In Vitro Use Guide
Unknown
Name Type Language
KETOROLAC TROMETHAMINE, (S)-
Common Name English
1,3-PROPANEDIOL, 2-AMINO-2-(HYDROXYMETHYL)-, (1S)-5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLATE (SALT)
Common Name English
1H-PYRROLIZINE-1-CARBOXYLIC ACID, 5-BENZOYL-2,3-DIHYDRO-, (1S)-, COMPD. WITH 2-AMINO-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL (1:1)
Systematic Name English
Code System Code Type Description
FDA UNII
E84R314D35
Created by admin on Sat Dec 16 10:53:33 GMT 2023 , Edited by admin on Sat Dec 16 10:53:33 GMT 2023
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CAS
156699-13-7
Created by admin on Sat Dec 16 10:53:33 GMT 2023 , Edited by admin on Sat Dec 16 10:53:33 GMT 2023
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PUBCHEM
73416230
Created by admin on Sat Dec 16 10:53:33 GMT 2023 , Edited by admin on Sat Dec 16 10:53:33 GMT 2023
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