Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C15H13NO3.C4H11NO3 |
Molecular Weight | 376.4037 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(CO)(CO)CO.OC(=O)[C@H]1CCN2C1=CC=C2C(=O)C3=CC=CC=C3
InChI
InChIKey=BWHLPLXXIDYSNW-MERQFXBCSA-N
InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2/t11-;/m0./s1
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL221 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9549656 |
0.46 µM [IC50] | ||
Target ID: CHEMBL230 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9549656 |
1.46 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac. | 1986 Apr |
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The pharmacokinetics of ketorolac enantiomers following intramuscular administration of the racemate. | 1994 Jan |
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Preclinical enantioselective pharmacology of (R)- and (S)- ketorolac. | 1998 Feb |
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Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen. | 1999 Feb 15 |
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Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats. | 1999 Jul |
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Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. | 1999 Mar |
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Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics. | 2017 Sep |
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E84R314D35
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156699-13-7
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73416230
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admin on Sat Dec 16 10:53:33 GMT 2023 , Edited by admin on Sat Dec 16 10:53:33 GMT 2023
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SUBSTANCE RECORD