Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H18ClNO4 |
| Molecular Weight | 335.782 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(OC1=CC=C(Cl)C=C1)C(=O)OCC2=NC(CO)=CC=C2
InChI
InChIKey=YJBIJSVYPHRVCI-UHFFFAOYSA-N
InChI=1S/C17H18ClNO4/c1-17(2,23-15-8-6-12(18)7-9-15)16(21)22-11-14-5-3-4-13(10-20)19-14/h3-9,20H,10-11H2,1-2H3
Pirifibrate is a fibric acid derivative. Pirifibrate was used in the treatment of hyperlipoproteinemia (HLP). After treatment with pirifibrate, mean plasma levels of cholesterol fell about 20% in types IIa and IIb HLP; triglycerides fell between 30% and 46% in types IIb and IV HLP. Slight increases in alpha-lipoproteins in the three types of HLP were measured. Prebeta-lipoprotein levels fell considerably in types IIb and IV. The variations observed in beta-lipoprotein levels were significant only in type IV, which initially showed low values.
Originator
Approval Year
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NCI_THESAURUS |
C98150
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ACTIVE MOIETY
