MEPIPERPHENIDOL BROMIDE

US Previously Marketed

First approved in 1953

[Br-].CC(C)C(C(O)CC[N+]1(C)CCCCC1)C2=CC=CC=C2

InChIKey=CALMOSBYAPVNLT-UHFFFAOYSA-M

InChI=1S/C19H32NO.BrH/c1-16(2)19(17-10-6-4-7-11-17)18(21)12-15-20(3)13-8-5-9-14-20;/h4,6-7,10-11,16,18-19,21H,5,8-9,12-15H2,1-3H3;1H/q+1;/p-1

Doses

Dose	Population	Adverse events
300 mg single, intramuscular Highest studied dose Dose: 300 mg Route: intramuscular Route: single Dose: 300 mg Sources: https://pubmed.ncbi.nlm.nih.gov/13331850	healthy, 18-29 years Health Status: healthy Age Group: 18-29 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/13331850	Other AEs: Drowsiness... Other AEs: Drowsiness Sources: https://pubmed.ncbi.nlm.nih.gov/13331850

AEs

AE	Significance	Dose	Population
Drowsiness		300 mg single, intramuscular Highest studied dose Dose: 300 mg Route: intramuscular Route: single Dose: 300 mg Sources: https://pubmed.ncbi.nlm.nih.gov/13331850	healthy, 18-29 years Health Status: healthy Age Group: 18-29 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/13331850

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

Other Inhibitor	Other Substrate	Other Inducer
OCT transporters 14

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
OCT transporters 14	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/8263763/; https://pubmed.ncbi.nlm.nih.gov/3171979/; https://pubmed.ncbi.nlm.nih.gov/2141764/	yes

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L1VLD
ABI Chem	AC1Q779R
NCI Plated 2007	17126
ZINC	ZINC000000000455	http://zinc15.docking.org/substances/ZINC000000000455
ZINC	ZINC000001747999	http://zinc15.docking.org/substances/ZINC000001747999
ZINC	ZINC000001748000	http://zinc15.docking.org/substances/ZINC000001748000
ZINC	ZINC000001748002	http://zinc15.docking.org/substances/ZINC000001748002

Patents

Name

Type

Language

MEPIPERPHENIDOL BROMIDE

Common Name

English

DARSTINE

Preferred Name

English

NSC-17126

Code

English

1-(3-HYDROXY-5-METHYL-4-PHENYLHEXYL)-1-METHYLPIPERIDINIUM BROMIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

E6OI36057B