GDC-0879

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H18N4O2
Molecular Weight	334.3718
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

SMILES

OCCN1C=C(C(=N1)C2=CC=NC=C2)C3=CC4=C(C=C3)\C(CC4)=N\O

InChI

InChIKey=DEZZLWQELQORIU-RELWKKBWSA-N

InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,24-25H,2,4,9-10H2/b22-18+

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Serine/threonine-protein kinase RAF 11	Inhibitor 8,504		0.54 nM [Ki]
Serine/threonine-protein kinase B-raf 21	Inhibitor 8,504		0.17 nM [Ki]

Show entries

Name

Type

Language

AR-00341677

Preferred Name

English

GDC-0879

Code

English

1H-INDEN-1-ONE, 2,3-DIHYDRO-5-(1-(2-HYDROXYETHYL)-3-(4-PYRIDINYL)-1H-PYRAZOL-4-YL)-, OXIME, (1E)-

Systematic Name

English

(E)-5-(1-(2-HYDROXYETHYL)-3-(PYRIDIN-4-YL)-1H-PYRAZOL-4-YL)-2,3-DIHYDRO-1H-INDEN-1-ONE

Systematic Name

English

1H-INDEN-1-ONE, 2,3-DIHYDRO-5-(1-(2-HYDROXYETHYL)-3-(4-PYRIDINYL)-1H-PYRAZOL-4-YL)-, OXIME

Systematic Name

English

Showing 1 to 5 of 7 entries

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Code System

Code

Type

Description

CAS

2230954-03-5

PRIMARY

CAS

905281-76-7

NON-SPECIFIC STEREOCHEMISTRY

PUBCHEM

11717001

PRIMARY

EPA CompTox

DTXSID00471110

PRIMARY

FDA UNII

E488J6BA6E

PRIMARY

Showing 1 to 5 of 5 entries

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ACTIVE MOIETY


					E488J6BA6E

GDC-0879