Adult under 65 years old: 1 to 2 tablets a day, taken once; the dose is adjusted according to blood glucose. The person over 65 or weakened: the initial dose is 1/2 tablet daily. Adjustment of the dosage is then made, depending on the blood glucose, in stages of at least 15 days.

It was observed the effect of BZ-55 (carbutamide) on one of the fundamental ways by which glucose is produced by the body. Slices of 60-90 mg weight were taken from the liver of a fed, normal rabbit. These slices were incubated in a phosphate-saline medium, pH 7.5, for 45 minutes, and the amounts of glucose produced by the slices were measured. Various amounts of BZ-55 (0.03; 0.06; 0.12; 0.25; 0.50 mg/ml) were added to the media, and in some cases insulin (1 unit/ml) or glucagon (2.5 y/ml) or insulin and glucagon were also added. Statistical analyses suggested that there was an inhibitory effect of BZ-55 upon glucose production in the absence of added insulin or glucagon.