Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H24O5 |
| Molecular Weight | 380.4337 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C\C=C(\C)C1=CC(O)=C(C)C2=C1OC3=C(C)C(O)=CC(\C(C)=C/C)=C3C(=O)O2
InChI
InChIKey=JJMKBGPTPXPMBH-OXAWKVHCSA-N
InChI=1S/C23H24O5/c1-7-11(3)15-9-17(24)13(5)20-19(15)23(26)28-21-14(6)18(25)10-16(12(4)8-2)22(21)27-20/h7-10,24-25H,1-6H3/b11-7-,12-8-
Folipastatin is a depsone metabolite first isolated from Aspergillus unguis by researchers at Sankyo, Japan in 1992 as an inhibitor of phospholipase A2. Folipastatin also possesses moderate antibiotic activity as against Gram positive bacteria. It is a component of a mixture of unguinol-related metabolites produced by A. unguis and A. nidulins patented as growth
promotants in livestock. More recently, folipastatin was reported as an inhibitor of sterol O-acyltransferase (SOAT) 1 and 2 iso-enzymes in cell-based and enzyme assays.
Originator
Approval Year
Sample Use Guides
Rats: When administered topically, folipastatin showed anti-inflammatory activity to the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema at 0.5mg per rat or mouse.
Route of Administration:
Topical
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
6439424
Created by
admin on Mon Mar 31 21:05:07 GMT 2025 , Edited by admin on Mon Mar 31 21:05:07 GMT 2025
|
PRIMARY | |||
|
E323392EAO
Created by
admin on Mon Mar 31 21:05:07 GMT 2025 , Edited by admin on Mon Mar 31 21:05:07 GMT 2025
|
PRIMARY | |||
|
139959-71-0
Created by
admin on Mon Mar 31 21:05:07 GMT 2025 , Edited by admin on Mon Mar 31 21:05:07 GMT 2025
|
PRIMARY |
SUBSTANCE RECORD
