BENZIMIDAZOLE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H6N2
Molecular Weight	118.1359
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N1C=NC2=C1C=CC=C2

InChI

InChIKey=HYZJCKYKOHLVJF-UHFFFAOYSA-N

InChI=1S/C7H6N2/c1-2-4-7-6(3-1)8-5-9-7/h1-5H,(H,8,9)

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Novel benzimidazole derivatives selectively inhibit endothelial cell growth and suppress angiogenesis in vitro and in vivo.	2002-09-08	12049814
Crystals of tryptophan indole-lyase and tyrosine phenol-lyase form stable quinonoid complexes.	2002-06-14	11934889
5-HT(4) receptor antagonists: structure-affinity relationships and ligand-receptor interactions.	2002-06	12052197
Oxidized derivatives of Octopus vulgaris and Carcinus aestuarii hemocyanins at pH 7.5 and related models by x-ray absorption spectroscopy.	2002-06	12023249
Stereocontrolled synthesis of heterocyclic C-nucleosides. Protecting group effect and molecular modeling studies.	2002-05-31	12027686
UV monitoring of microwave-heated reactions--a feasibility study.	2002-05-17	12012409
Distribution of furamidine analogues in tumor cells: influence of the number of positive charges.	2002-05-09	11985467
Benzimidazole-based fXa inhibitors with improved thrombin and trypsin selectivity.	2002-05-06	11965378
Design and synthesis of aminophenol-based factor Xa inhibitors.	2002-05-06	11965377
Synthesis and preliminary evaluation of benzimidazole derivatives as antimicrobial agents.	2002-05	12008055
Excision of a proposed electron transfer pathway in cytochrome c peroxidase and its replacement by a ligand-binding channel.	2002-05	11967381
Mitochondrial DNA variation in benzimidazole-resistant and -susceptible populations of the small ruminant parasite Teladorsagia circumcincta.	2002-04-12	11948218
Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzimidazole resistance?	2002-04-09	11897135
Liquid-phase combinatorial synthesis of aminobenzimidazoles.	2002-04-08	11909703
Drug design at peptide receptors: somatostatin receptor ligands.	2002-04-05	11931345
Intermediacy of an N-heterocyclic carbene complex in the catalytic C-H activation of a substituted benzimidazole.	2002-04-03	11916392
Benzimidazole binding to Haemonchus contortus tubulin: a question of structure.	2002-04	11998698
New benzimidazole derivatives as antimycobacterial agents.	2002-04	11989805
A novel ABC transporter gene, PMR5, is involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum.	2002-04	11976961
Comparative thermodynamics for monomer and dimer sequence-dependent binding of a heterocyclic dication in the DNA minor groove.	2002-03-29	11922670
Correlation of the melting points of potential ionic liquids (imidazolium bromides and benzimidazolium bromides) using the CODESSA program.	2002-03-26	11911691
Formation in vitro of hybrid dimers of H463F and Y74F mutant Escherichia coli tryptophan indole-lyase rescues activity with L-tryptophan.	2002-03-26	11900544
Synthesis, characterization and antiamoebic activity of benzimidazole derivatives and their vanadium and molybdenum complexes.	2002-03-25	11958982
Modulating the reduction potential of mononuclear cobalt(II) complexes via selective deprotonation of tris[(2-benzimidazolyl)methyl]amine.	2002-03-25	11896700
Determination of omeprazole and its metabolites in human plasma by liquid chromatography-mass spectrometry.	2002-03-08	11999727
Aromatic amination/imination approach to chiral benzimidazoles.	2002-03-08	11871911
Novel synthetic retinoids and separation of the pleiotropic retinoidal activities.	2002-03	11945126
Triclabendazole-resistant Fasciola hepatica: beta-tubulin and response to in vitro treatment with triclabendazole.	2002-03	11922434
Synthesis, antimicrobial and molluscicidal activities of new benzimidazole derivatives.	2002-02	11885688
Characteristics of a flubendazole resistant isolate of Oesophagostomum dentatum from Germany.	2002-01-03	11751004
[Regulation of cytochrome P-450 (CYP) genes by nuclear receptors].	2002-01	11868391
Prevalence of levamisole and benzimidazole resistance in oesophagostomum populations of pig-breeding farms in North Rhine-Westphalia, Germany.	2002-01	11822739
Azole-linked coumarin dyes as fluorescence probes of domain-forming polymers.	2001-12-01	11747999
Prevalence of anthelmintic resistance in gastrointestinal nematodes of dairy goats under extensive management conditions in southwestern France.	2001-12	11818048
Toxocariasis in humans: clinical expression and treatment dilemma.	2001-12	11818044
Development and validation of a liquid chromatography-electrospray tandem mass spectrometry method for mebendazole and its metabolites hydroxymebendazole and aminomebendazole in sheep liver.	2001-12	11814193
Replacement of oral proton pump inhibitors with intravenous pantoprazole to effectively control gastric acid hypersecretion in patients with Zollinger-Ellison syndrome.	2001-12	11774936
Molecular approaches to studying benzimidazole resistance in trichostrongylid nematode parasites of small ruminants.	2001-11-22	11707309
Total synthesis of nucleobase-modified adenophostin A mimics.	2001-11-19	11763462
Enzymatic activity of coenzyme B(12) derivatives with altered axial nucleotides: probing the mechanochemical triggering hypothesis in ribonucleotide reductase.	2001-11-05	11681909
Potent, low molecular weight thrombin receptor antagonists.	2001-11-05	11597414
3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT(4) receptor.	2001-11-05	11597405
Novel peptidomimetics of the antifungal cyclic peptide Rhodopeptin: design of mimetics utilizing scaffolding methodology.	2001-11-01	11678679
Synthesis and antiviral assays of some benzimidazole nucleosides and acyclonucleosides.	2001-11	11765032
Iminocoumarin-based low affinity fluorescent Ca2+ indicators excited with visible light.	2001-11	11733939
Prospects in medical management of Echinococcus granulosus.	2001-10-27	11677989
Lansoprazole: pharmacokinetics, pharmacodynamics and clinical uses.	2001-10	11825309
Preparation, physicochemical characterization and pharmacological study of novel ruthenium(III) complexes with imidazole and benzimidazole derivatives.	2001-09	11642009
Enantioselective analysis of albendazole sulfoxide in cerebrospinal fluid by capillary electrophoresis.	2001-09	11589289
The dynamics, prevalence and impact of nematode infections in organically raised sheep in Sweden.	2001	11887398

Patents

Name

Type

Language

BENZIMIDAZOLE

Official Name

English

NSC-759

Preferred Name

English

BENZIMIDAZOLE [MI]

Common Name

English

BENZIMIDAZOLE [HSDB]

Common Name

English

1H-BENZIMIDAZOLE

Systematic Name

English

1,3-BENZODIAZOLE

Systematic Name

English

Code System Code Type Description

MERCK INDEX

m2353