Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H5NO3 |
| Molecular Weight | 91.066 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCO[N+]([O-])=O
InChI
InChIKey=IDNUEBSJWINEMI-UHFFFAOYSA-N
InChI=1S/C2H5NO3/c1-2-6-3(4)5/h2H2,1H3
Ethyl nitrate is an inhaled organic nitrate that affects pulmonary vascular tone and may be used as a possible treatment for persistent pulmonary hypertension of the newborn. Ethyl nitrate acts by generating NO, which activates soluble guanylate cyclase to increase intracellular cyclic GMP. This, in turn, leads to a decrease in intracellular calcium and relaxation of the vascular smooth muscle.
Originator
Approval Year
Sample Use Guides
In a preclinical study, swine were treated with 0.0025, 0.025, 0.125, 1.25, 2.5% ethyl nitrate gas.
Route of Administration:
Respiratory
Rabbit pulmonary artery rings were exposed to phenylephrine to induce contraction and then liquid ethyl nitrate was added to the baths at an initial concentration of 1 nM and then increased 10-fold at a time to a final concentration of 0.1 mM. Dose-dependent relaxation was seen between 0.1 uM and 0.1 mM with pIC50 value of 4.5.
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C465446
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625-58-1
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415
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1314360
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C45678
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CONCEPT | Industrial Aid | ||
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100000156789
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210-903-3
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12259
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E1ZT886LR5
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DTXSID0060806
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C82283
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8826
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SUB130809
Created by
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ETHYL NITRATE
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E1ZT886LR5
Created by
admin on Fri Dec 15 15:34:44 GMT 2023 , Edited by admin on Fri Dec 15 15:34:44 GMT 2023
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PRIMARY |
SUBSTANCE RECORD
