U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C23H25FN2O
Molecular Weight 364.4558
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LEXANOPADOL

SMILES

CN[C@]1(CC[C@@]2(CC1)OCCC3=C2NC4=C3C=C(F)C=C4)C5=CC=CC=C5

InChI

InChIKey=AMXGKMSRYLZAEO-YHBQERECSA-N
InChI=1S/C23H25FN2O/c1-25-22(16-5-3-2-4-6-16)10-12-23(13-11-22)21-18(9-14-27-23)19-15-17(24)7-8-20(19)26-21/h2-8,15,25-26H,9-14H2,1H3/t22-,23-

HIDE SMILES / InChI
Lexanopadol is a potent ORL-1 agonist (opioid receptor like -1), nociceptin receptor agonists and opioid mu receptor agonists. Preliminary evidence suggests that targeting ORL-1 receptors may have synergistic effects with mu receptors hence enhancing the therapeutic profile of Lexanopadol in the treatment of pain. Lexanopadol is particularly suited for the management of moderate to severe chronic pain, including neuropathic pain. Lexanopadol hemicitrate is in phase II clinical trials for the treatment of pain. However there is no recent development reported.

Approval Year

Patents

Patents

Name Type Language
LEXANOPADOL
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
Lexanopadol [WHO-DD]
Common Name English
lexanopadol [INN]
Common Name English
GRT-13106G
Code English
LEXANOPADOL [USAN]
Common Name English
GRT13106G
Code English
GRT-6006
Code English
GRT6006
Code English
TRANS-6'-FLUORO-N-METHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO(CYCLOHEXANE-1,1'-PYRANO(3,4-B)INDOL)-4-AMINE
Systematic Name English
SPIRO(CYCLOHEXANE-1,1'(3'H)-PYRANO(3,4-B)INDOL)-4-AMINE, 6'-FLUORO-4',9'-DIHYDRO-N-METHYL-4-PHENYL-, TRANS-
Common Name English
Code System Code Type Description
NCI_THESAURUS
C170119
Created by admin on Sat Dec 16 09:02:52 GMT 2023 , Edited by admin on Sat Dec 16 09:02:52 GMT 2023
PRIMARY
CAS
1357348-09-4
Created by admin on Sat Dec 16 09:02:52 GMT 2023 , Edited by admin on Sat Dec 16 09:02:52 GMT 2023
PRIMARY
FDA UNII
DZ4NDW1LZX
Created by admin on Sat Dec 16 09:02:52 GMT 2023 , Edited by admin on Sat Dec 16 09:02:52 GMT 2023
PRIMARY
SMS_ID
300000034332
Created by admin on Sat Dec 16 09:02:52 GMT 2023 , Edited by admin on Sat Dec 16 09:02:52 GMT 2023
PRIMARY
ChEMBL
CHEMBL3301613
Created by admin on Sat Dec 16 09:02:52 GMT 2023 , Edited by admin on Sat Dec 16 09:02:52 GMT 2023
PRIMARY
PUBCHEM
24798598
Created by admin on Sat Dec 16 09:02:52 GMT 2023 , Edited by admin on Sat Dec 16 09:02:52 GMT 2023
PRIMARY
INN
9765
Created by admin on Sat Dec 16 09:02:52 GMT 2023 , Edited by admin on Sat Dec 16 09:02:52 GMT 2023
PRIMARY
USAN
BC-23
Created by admin on Sat Dec 16 09:02:52 GMT 2023 , Edited by admin on Sat Dec 16 09:02:52 GMT 2023
PRIMARY