M-3258

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H20BNO5
Molecular Weight	329.155
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OB(O)[C@H](CC1=COC2=CC=CC=C12)NC(=O)[C@@H]3C[C@H]4CC[C@@H]3O4

InChI

InChIKey=RFQDLTYXNINJON-OYNZBZHQSA-N

InChI=1S/C17H20BNO5/c20-17(13-8-11-5-6-15(13)24-11)19-16(18(21)22)7-10-9-23-14-4-2-1-3-12(10)14/h1-4,9,11,13,15-16,21-22H,5-8H2,(H,19,20)/t11-,13-,15+,16+/m1/s1

HIDE SMILES / InChI

Approval Year

C_max

Value	Dose	Analyte	Population
153 ng/mL CLINICAL TRIAL https://clinicaltrials.gov/ct2/show/results/NCT04075721	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:	M-3258 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
215 ng/mL CLINICAL TRIAL https://clinicaltrials.gov/ct2/show/results/NCT04075721	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:	M-3258 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
213 ng/mL CLINICAL TRIAL https://clinicaltrials.gov/ct2/show/results/NCT04075721	10 mg 2 times / week multiple, oral dose: 10 mg route of administration: Oral experiment type: MULTIPLE co-administered:	M-3258 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
511 ng/mL CLINICAL TRIAL https://clinicaltrials.gov/ct2/show/results/NCT04075721	20 mg 2 times / week multiple, oral dose: 20 mg route of administration: Oral experiment type: MULTIPLE co-administered:	M-3258 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
2000 ng × h/mL CLINICAL TRIAL https://clinicaltrials.gov/ct2/show/results/NCT04075721	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:		M-3258 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3300 ng × h/mL CLINICAL TRIAL https://clinicaltrials.gov/ct2/show/results/NCT04075721	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:		M-3258 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
2.69% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36273822/			M-3258 plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Name

Type

Language

M-3258

Common Name

English

LMP7-IN-1

Preferred Name

English

((R)-2-(Benzofuran-3-yl)-1-((1S,2R,4R)-7-oxabicyclo[2.2.1]heptane-2-carboxamido)ethyl)boronic acid

Systematic Name

English

B-[(1R)-2-(3-Benzofuranyl)-1-[[(1S,2R,4R)-7-oxabicyclo[2.2.1]hept-2-ylcarbonyl]amino]ethyl]boronic acid

Systematic Name

English

M3258

Code

English

Boronic acid, B-[(1R)-2-(3-benzofuranyl)-1-[[(1S,2R,4R)-7-oxabicyclo[2.2.1]hept-2-ylcarbonyl]amino]ethyl]-

Systematic Name

English

Code System Code Type Description

CAS

2285330-15-4

Created by admin on Wed Apr 02 00:23:04 GMT 2025 , Edited by admin on Wed Apr 02 00:23:04 GMT 2025

PRIMARY

PUBCHEM

138319683

Created by admin on Wed Apr 02 00:23:04 GMT 2025 , Edited by admin on Wed Apr 02 00:23:04 GMT 2025

PRIMARY

FDA UNII

DYU0SZB8VA

Created by admin on Wed Apr 02 00:23:04 GMT 2025 , Edited by admin on Wed Apr 02 00:23:04 GMT 2025

PRIMARY

ACTIVE MOIETY


					DYU0SZB8VA

M-3258

Details

SMILES

InChI

Approval Year

Cmax

AUC

Funbound

C_max

F_unbound