Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | AsHO2 |
| Molecular Weight | 107.9283 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O[As]=O
InChI
InChIKey=XHTRYVMKFMUJLU-UHFFFAOYSA-N
InChI=1S/AsHO2/c2-1-3/h(H,2,3)
Sodium arsenite is an inoganic sodium salt with formula with formula NaAsO2. It has a role as an insecticide, an antibacterial agent, a herbicide, a rodenticide, a carcinogenic agent, an antineoplastic agent and an antifungal agent. It is an arsenic molecular entity and an inorganic sodium salt. Sodium arsenite demonstrated in vitro scolicidal effect against E. granulosus protoscoleces. Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis. Sodium arsenite is an effective drug for the treatment of acute promyelocytic leukemia with little nonspecific toxicity. Sodium metaarsenite (KML-001) displaces hTERT from the nucleus and is synergistic with cisplatin. It was used in the clinical trials for the treatment of advanced solid tumors.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis. | 2003-08-01 |
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| Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes. | 2003-05-16 |
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| Identification of galectin I and thioredoxin peroxidase II as two arsenic-binding proteins in Chinese hamster ovary cells. | 2003-04-15 |
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| Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. | 2003-04-11 |
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| Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. | 2003-04 |
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| Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF. | 2003-03-27 |
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| Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1. | 2003-03-21 |
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| Stress-induced gene expression requires programmed recovery from translational repression. | 2003-03-03 |
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| Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation. | 2003-03-01 |
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| Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats. | 2003-03 |
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| Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. | 2003-02-28 |
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| Heat shock induces intestinal-type alkaline phosphatase in rat IEC-18 cells. | 2003-02 |
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| Differential activation of AP-1 in human bladder epithelial cells by inorganic and methylated arsenicals. | 2003-01 |
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| Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology. | 2002-12 |
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| Effects of ascorbic acid and alpha-tocopherol on arsenic-induced oxidative stress. | 2002-12 |
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| Induction of heat shock proteins (HSPs) by sodium arsenite in cultured astrocytes and reduction of hydrogen peroxide-induced cell death. | 2002-12 |
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| Upregulation of glutathione-related genes and enzyme activities in cultured human cells by sublethal concentrations of inorganic arsenic. | 2002-12 |
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| Differential influences of various arsenic compounds on glutathione redox status and antioxidative enzymes in porcine endothelial cells. | 2002-11 |
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| Acute arsenite-induced 8-hydroxyguanine is associated with inhibition of repair activity in cultured human cells. | 2002-10-04 |
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| Arsenic induces peroxynitrite generation and cyclooxygenase-2 protein expression in aortic endothelial cells: possible role in atherosclerosis. | 2002-10-01 |
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| Sodium arsenite-induced stress-related gene expression in normal human epidermal, HaCaT, and HEL30 keratinocytes. | 2002-10 |
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| Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes. | 2002-10 |
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| Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-kappaB activity. | 2002-10 |
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| Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. | 2002-09-15 |
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| Involvement of reactive oxygen species in arsenite-induced downregulation of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells. | 2002-09-15 |
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| Expression of hsp 90 in the human kidney and in proximal tubule cells exposed to heat, sodium arsenite and cadmium chloride. | 2002-07-21 |
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| Effect of arsenic on transcription factor AP-1 and NF-kappaB DNA binding activity and related gene expression. | 2002-07-07 |
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| The stress response decreases NF-kappaB activation in liver of endotoxemic mice. | 2002-07 |
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| Differential expression of two stress-inducible hsp70 genes by various stressors. | 2002-05-31 |
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| A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis. | 2002-05 |
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| Changes in gene expression profiles of human fibroblasts in response to sodium arsenite treatment. | 2002-05 |
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| Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice. | 2002-05 |
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| Role of Ras in metal-induced EGF receptor signaling and NF-kappaB activation in human airway epithelial cells. | 2002-05 |
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| Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells. | 2002-04 |
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| Mapping of the chick heme oxygenase-1 proximal promoter for responsiveness to metalloporphyrins. | 2002-03-15 |
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| Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. | 2002-03 |
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| Sodium arsenite inhibits and reverses expression of adipogenic and fat cell-specific genes during in vitro adipogenesis. | 2002-02 |
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| c-Src-dependent activation of the epidermal growth factor receptor and mitogen-activated protein kinase pathway by arsenic. Role in carcinogenesis. | 2002-01-25 |
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| Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. | 2002-01-15 |
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| Differential accumulation of U14 snoRNA and hsc70 mRNA in Chinese hamster cells after exposure to various stress conditions. | 2002-01 |
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| Involvement of p38 mitogen-activated protein kinase in the cell growth inhibition by sodium arsenite. | 2002-01 |
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| Arsenic induces oxidative stress and activates stress gene expressions in cultured lung epithelial cells. | 2002 |
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| Acute sodium arsenite treatment induces Cyp2a5 but not Cyp1a1 in the C57Bl/6 mouse in a tissue (kidney) selective manner. | 2002 |
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| Arsenite stimulates cyclooxygenase-2 expression through activating IkappaB kinase and nuclear factor kappaB in primary and ECV304 endothelial cells. | 2002 |
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| Arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1 beta-stimulated Caco-2 cells independent of the heat shock response. | 2002 |
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| Sodium arsenite suppresses human papillomavirus-16 E6 gene and enhances apoptosis in E6-transfected human lymphoblastoid cells. | 2002 |
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| Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. | 2001-12-21 |
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| p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line. | 2001-11 |
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| Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells. | 2001-10-26 |
|
| [Effects of inorganic arsenicals on the methylation of p16 gene CpG islands and the expression of p16 gene in BEP2D cells]. | 2001-10-25 |
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Patients with advanced solid tumors: treatment was with cisplatin i.v. 75 mg/m2 day 1 and metaarsenite (KML-001) (7.5-20 mg) p.o. daily days 1-14 on a 21-day cycle. A standard 3 + 3 design was employed. https://www.ncbi.nlm.nih.gov/pubmed/27620207
Swiss albino male mice were exposed to sodium arsenite in drinking water at concentrations of 10, 50,100, and 200 mg/l for a period of three months.
Route of Administration:
Oral
In Vitro Use Guide
Curator's Comment: Protoscoleces of E. granulosus were incubated in vitro with 4, 8, 12, 16, and 20uM sodium arsenite (NaAsO2). Obvious protoscolicidal effect was seen with NaAsO2 at concentrations of 16uM and 20uM. Protoscolex mortality was 83.24% (16uM) and 100% (20uM) after 6 days post-incubation. https://www.ncbi.nlm.nih.gov/pubmed/27234209
Immunoblots showed an increased expression of p53 gene with 1 uM sodium arsenite in Jurkat cells and 10 uM sodium arsenite in HeLa and LCL-EBV cells.
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SALT/SOLVATE (PARENT)
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SUBSTANCE RECORD
