Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H8O2 |
| Molecular Weight | 136.1479 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCC(=O)C1=CC=CC=C1
InChI
InChIKey=ZWVHTXAYIKBMEE-UHFFFAOYSA-N
InChI=1S/C8H8O2/c9-6-8(10)7-4-2-1-3-5-7/h1-5,9H,6H2
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| NPY and NPY Y1 receptor effects on noradrenaline overflow from the rat brain in vitro. | 2004-08-15 |
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| Possible involvement of group I mGluRs in neuroprotective effect of theanine. | 2004-07-16 |
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| Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. | 2004-07 |
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| Clinical assessment of norepinephrine transporter blockade through biochemical and pharmacological profiles. | 2004-06-29 |
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| Glutamate-induced elevations in intracellular chloride concentration in hippocampal cell cultures derived from EYFP-expressing mice. | 2004-06 |
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| Estimations of excited state dipole moments of conformers in some o-substituted acetophenones by solvato-chromic shifts. | 2004-06 |
|
| Using model complexes to augment and advance metalloproteinase inhibitor design. | 2004-05-17 |
|
| Evidence that phospholipase D activation prevents group I mGluR-induced persistent prolongation of epileptiform bursts. | 2004-05 |
|
| Mechanisms of postspaceflight orthostatic hypotension: low alpha1-adrenergic receptor responses before flight and central autonomic dysregulation postflight. | 2004-04 |
|
| Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression. | 2004-03-26 |
|
| Method for simultaneous measurement of norepinephrine, 3-methoxy-4-hydroxyphenylglycol and 3,4-dihydroxyphenylglycol by liquid chromatography with electrochemical detection: application in rat cerebral cortex and plasma after lithium chloride treatment. | 2004-03-05 |
|
| Modulation of rhythmic patterns and cumulative depolarization by group I metabotropic glutamate receptors in the neonatal rat spinal cord in vitro. | 2004-02 |
|
| Alpha-hydroxyketones as inhibitors of urease. | 2004-01-15 |
|
| Expression and functional properties of group I metabotropic glutamate receptors in bovine chromaffin cells. | 2004-01-15 |
|
| Modulation of afterpotentials and firing pattern in guinea pig CA3 neurones by group I metabotropic glutamate receptors. | 2004-01-15 |
|
| Extracellular signal-regulated kinase 1/2 is required for the induction of group I metabotropic glutamate receptor-mediated epileptiform discharges. | 2004-01-07 |
|
| Prenatal infection obliterates glutamate-related protection against free hydroxyl radicals in neonatal rat brain. | 2004-01-01 |
|
| Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons. | 2004-01 |
|
| Design and synthesis of two pyrazole libraries based on o-hydroxyacetophenones. | 2004 |
|
| Mu opioid modulation of oxytocin secretion in late pregnant and parturient rats. Involvement of noradrenergic neurotransmission. | 2004 |
|
| Blockade of excitatory amino acid transporters in the rat hippocampus results in enhanced activation of group I and group III metabotropic glutamate receptors. | 2003-12 |
|
| Hippocampal mGluR1 and consolidation of contextual fear conditioning. | 2003-11-15 |
|
| Evidence for a relationship between Group 1 mGluR hypofunction and increased cocaine and ethanol sensitivity in Homer2 null mutant mice. | 2003-11 |
|
| Elucidation of Homer 1a function in the nucleus accumbens using adenovirus gene transfer technology. | 2003-11 |
|
| Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta. | 2003-11 |
|
| mGluRs: a target for pharmacotherapy in Parkinson disease. | 2003-11 |
|
| In vivo monitoring of norepinephrine and its metabolites in skeletal muscle. | 2003-11 |
|
| Changes in hippocampal gene expression after neuroprotective activation of group I metabotropic glutamate receptors. | 2003-10-07 |
|
| Distinct subtypes of group I metabotropic glutamate receptors on rat spinal neurons mediate complex facilitatory and inhibitory effects. | 2003-10 |
|
| Involvement of transient receptor potential-like channels in responses to mGluR-I activation in midbrain dopamine neurons. | 2003-10 |
|
| Electroencephalographic burst suppression versus loss of reflexes anesthesia with propofol or thiopental: differences of variance in the catecholamine and cardiovascular response to tracheal intubation. | 2003-10 |
|
| Hydroxyl radicals release in rat striatum involves metabotropic glutamate receptors. | 2003-08-30 |
|
| Endocannabinoids contribute to short-term but not long-term mGluR-induced depression in the hippocampus. | 2003-08 |
|
| Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. | 2003-07-17 |
|
| Group I mGluR ligands fail to affect 6-hydroxydopamine- induced death and glutamate release of PC12 cells. | 2003-07 |
|
| Intracellular calcium release resulting from mGluR1 receptor activation modulates GABAA currents in wide-field retinal amacrine cells: a study with caffeine. | 2003-06 |
|
| 6-(2-Hydroxybenzoyl)-5-(pyrrol-2-yl)-3H-pyrrolizine. | 2003-06 |
|
| Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability. | 2003-05-08 |
|
| Acute electrophysiologic effects of intravenous amiodarone are independent of a sympatholytic action in humans. | 2003-05 |
|
| Spectroscopic studies on chromotropic mixed-ligand copper(II) complexes containing o-hydroxy benzoyl derivatives and dinitrogen bases. | 2003-05 |
|
| Plasma levels of catechols and metanephrines in neurogenic orthostatic hypotension. | 2003-04-22 |
|
| Spectral studies and structure of a 2-hydroxyacetophenone 3-hexamethyleneiminyl thiosemicarbazonate(-2) copper(II) complex containing 1,10-phenanthroline. | 2003-04 |
|
| Group I metabotropic glutamate receptor activation produces prolonged epileptiform neuronal synchronization and alters evoked population responses in the hippocampus. | 2003-03 |
|
| Interactions between adenosine and metabotropic glutamate receptors in the rat hippocampal slice. | 2003-03 |
|
| Acute activation of the spinal cord metabotropic glutamate subtype-5 receptor leads to cold hypersensitivity in the rat. | 2003-03 |
|
| Group I metabotropic glutamate receptor-mediated calcium signalling and immediate early gene expression in cultured rat striatal neurons. | 2003-02 |
|
| Mechanisms underlying the inhibition of long-term potentiation by preconditioning stimulation in the hippocampus in vitro. | 2003 |
|
| The role of Ca2+ in the generation of spontaneous astrocytic Ca2+ oscillations. | 2003 |
|
| Dual modulation of gabaergic transmission by metabotropic glutamate receptors in rat ventral tegmental area. | 2003 |
|
| Effect of microgravity on plasma catecholamine responses to stressors during space flight. | 2001-07 |
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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JECFA EVALUATION |
2-HYDROXYACETOPHENONE
Created by
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| Code System | Code | Type | Description | ||
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28341
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171232
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1919492
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582-24-1
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68490
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DQ1N9R01IA
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DTXSID7060388
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209-480-8
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DQ1N9R01IA
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SUBSTANCE RECORD
