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Details

Stereochemistry ABSOLUTE
Molecular Formula C17H18N5O6S2.Na
Molecular Weight 475.474
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of CEFOVECIN SODIUM

SMILES

[Na+].[H][C@]12SCC([C@@H]3CCCO3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C4=CSC(N)=N4)C([O-])=O

InChI

InChIKey=QRIBXVGHDLFNNE-VQWMGBAQSA-M
InChI=1S/C17H19N5O6S2.Na/c1-27-21-10(8-6-30-17(18)19-8)13(23)20-11-14(24)22-12(16(25)26)7(5-29-15(11)22)9-3-2-4-28-9;/h6,9,11,15H,2-5H2,1H3,(H2,18,19)(H,20,23)(H,25,26);/q;+1/p-1/b21-10-;/t9-,11+,15+;/m0./s1

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: http://www.zora.uzh.ch/40272/4/Cefovecin.pdf | http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/veterinary/000098/WC500062064.pdf

Cefovecin is a third generation cephalosporin with a broad-spectrum of activity against Gram-positive and Gram-negative bacteria. Cefovecin differs from other cephalosporins in that it is highly protein bound and has a long duration of activity. As with all cephalosporins, the bactericidal action of cefovecin results from the inhibition of bacterial cell wall synthesis through binding to the penicillin-binding proteins (PBPs). It is indicated for the treatment of skin infections secondary superficial pyoderma, abscesses and wounds. Some gastrointestinal adverse effects like vomiting, anorexia or diarrhea were observed.

Originator

Curator's Comment: # Pfizer, Inc.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Convenia

Approved Use

CONVENIA is indicated for the treatment of skin infections (secondary superficial pyoderma, abscesses, and wounds) in dogs caused by susceptible strains of Staphylococcus intermedius and Streptococcus canis and skin infections (wounds and abscesses) in cats, caused by susceptible strains of Pasteurella multocida.

Launch Date

2008
Curative
Convenia

Approved Use

CONVENIA is indicated for the treatment of skin infections (secondary superficial pyoderma, abscesses, and wounds) in dogs caused by susceptible strains of Staphylococcus intermedius and Streptococcus canis and skin infections (wounds and abscesses) in cats, caused by susceptible strains of Pasteurella multocida.

Launch Date

2008
Curative
Convenia

Approved Use

CONVENIA is indicated for the treatment of skin infections (secondary superficial pyoderma, abscesses, and wounds) in dogs caused by susceptible strains of Staphylococcus intermedius and Streptococcus canis and skin infections (wounds and abscesses) in cats, caused by susceptible strains of Pasteurella multocida.

Launch Date

2008
PubMed

PubMed

TitleDatePubMed
Pharmacokinetics and pharmacodynamics of cefovecin in dogs.
2006 Dec
Pharmacokinetics of cefovecin in cats.
2006 Dec
Antimicrobial activity and spectrum of cefovecin, a new extended- spectrum cephalosporin, against pathogens collected from dogs and cats in Europe and North America.
2006 Jul
Patents

Sample Use Guides

A single injection of 8 mg/kg body weight. A second injection of 8 mg/kg may be administered if response to therapy is not complete.
Route of Administration: Other
The minimum inhibitory concentrations (MICs) were determined for 45 clinical Pasteurella multocida isolates from infections in cats using applicable Clinical and Laboratory Standards Institute (CLSI) standards. The MIC90 for P. multocida was ≤ 0.06 ug/mL.
Name Type Language
CEFOVECIN SODIUM
GREEN BOOK   JAN   MART.   USAN  
USAN  
Official Name English
CEFOVECIN SODIUM SALT [MI]
Common Name English
UK-287074-02
Code English
Sodium (6R,7R)-7-[[(2Z)-(2-aminothiazol-4-yl)(methoxyimino)acetyl]amino]-8-oxo-3-[(2S)-tetrahydrofuran-2-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Systematic Name English
CEFOVECIN SODIUM [USAN]
Common Name English
5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID, 7-(((2-AMINO-4-THIAZOLYL)(METHOXYIMINO)ACETYL)AMINO)-8-OXO-3-(TETRAHYDRO-2-FURANYL)-, MONOSODIUM SALT, (6R-(3(S*),6.ALPHA.,7.BETA.(Z)))-
Common Name English
CEFOVECIN SODIUM [MART.]
Common Name English
CEFOVECIN SODIUM [GREEN BOOK]
Common Name English
CEFOVECIN SODIUM [JAN]
Common Name English
UK-287,074-02
Code English
CEFOVECIN NATRIUM
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C357
Created by admin on Fri Dec 15 16:21:48 GMT 2023 , Edited by admin on Fri Dec 15 16:21:48 GMT 2023
Code System Code Type Description
DAILYMED
DL8Q24959P
Created by admin on Fri Dec 15 16:21:48 GMT 2023 , Edited by admin on Fri Dec 15 16:21:48 GMT 2023
PRIMARY
PUBCHEM
23690298
Created by admin on Fri Dec 15 16:21:48 GMT 2023 , Edited by admin on Fri Dec 15 16:21:48 GMT 2023
PRIMARY
EPA CompTox
DTXSID701016633
Created by admin on Fri Dec 15 16:21:48 GMT 2023 , Edited by admin on Fri Dec 15 16:21:48 GMT 2023
PRIMARY
FDA UNII
DL8Q24959P
Created by admin on Fri Dec 15 16:21:48 GMT 2023 , Edited by admin on Fri Dec 15 16:21:48 GMT 2023
PRIMARY
USAN
MM-54
Created by admin on Fri Dec 15 16:21:48 GMT 2023 , Edited by admin on Fri Dec 15 16:21:48 GMT 2023
PRIMARY
NCI_THESAURUS
C76036
Created by admin on Fri Dec 15 16:21:48 GMT 2023 , Edited by admin on Fri Dec 15 16:21:48 GMT 2023
PRIMARY
CAS
141195-77-9
Created by admin on Fri Dec 15 16:21:48 GMT 2023 , Edited by admin on Fri Dec 15 16:21:48 GMT 2023
PRIMARY
SMS_ID
300000023689
Created by admin on Fri Dec 15 16:21:48 GMT 2023 , Edited by admin on Fri Dec 15 16:21:48 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110625
Created by admin on Fri Dec 15 16:21:48 GMT 2023 , Edited by admin on Fri Dec 15 16:21:48 GMT 2023
PRIMARY
RXCUI
1591924
Created by admin on Fri Dec 15 16:21:48 GMT 2023 , Edited by admin on Fri Dec 15 16:21:48 GMT 2023
PRIMARY RxNorm
MERCK INDEX
m3207
Created by admin on Fri Dec 15 16:21:48 GMT 2023 , Edited by admin on Fri Dec 15 16:21:48 GMT 2023
PRIMARY Merck Index