U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C2H2F4
Molecular Weight 102.0309
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NORFLURANE

SMILES

FCC(F)(F)F

InChI

InChIKey=LVGUZGTVOIAKKC-UHFFFAOYSA-N
InChI=1S/C2H2F4/c3-1-2(4,5)6/h1H2

HIDE SMILES / InChI
Norflurane (1,1,1,2-Tetrafluoroethane) is a non-flammable gas used primarily as a "high-temperature" refrigerant for domestic refrigeration and automobile air conditioners. Other uses include plastic foam blowing, as a cleaning solvent, a propellant for the delivery of pharmaceuticals (e.g. bronchodilators), wine cork removers, gas dusters, and in air driers for removing the moisture from compressed air. Liquid Norflurane absorbs a high amount of thermal energy from the environment during its evaporation at atmospheric pressure. Norflurane is commercially available as a liquid in pressurized cylinders or cans. Norflurane is used as a propellant for some metered dose inhalers and as an inhalational anesthetic agent in animal studies.

Approval Year

PubMed

PubMed

TitleDatePubMed
Characterisation of the aggregation behaviour in a salmeterol and fluticasone propionate inhalation aerosol system.
2001 Jun 19
An atmospheric pressure chemical ionization study of the positive and negative ion chemistry of the hydrofluorocarbons 1,1-difluoroethane (HFC-152a) and 1,1,1,2-tetrafluoroethane (HFC-134a) and of perfluoro-n-hexane (FC-72) in air plasma at atmospheric pressure.
2004 Jul
Pulp responses to precise thermal stimuli in dentin-sensitive teeth.
2004 Jun
Medical aerosol propellant interference with infrared anaesthetic gas monitors.
2004 Jun
Application of magnetic resonance imaging to the investigation of the diffusivity of 1,1,1,2-tetrafluorethane in two polymers.
2004 Mar
Probing the internal competition between alpha- and beta-elimination by fluorine substitution in adsorbed ethyl groups on Cu(100).
2005 Nov 24
Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs.
2006 Jul
Toxicokinetics of 1,1,1,2-tetrafluoroethane (HFC-134a) in male volunteers after experimental exposure.
2006 Nov 1
Extrinsic allergic alveolitis with eosinophil infiltration induced by 1,1,1,2-tetrafluoroethane (HFC-134a): a case report.
2007
Effect of topical aerosol skin refrigerant (spray and stretch technique) on passive and active stretching.
2008 Apr
The validity of pulp testing: a clinical study.
2009 Aug
Efficacy of lamellar resection, cryotherapy, and adjunctive grafting for the treatment of canine limbal melanoma.
2009 Nov-Dec
A force field for 3,3,3-fluoro-1-propenes, including HFO-1234yf.
2010 Aug 12
Liquid-air partition coefficients of 1,1-difluoroethane (HFC152a), 1,1,1-trifluoroethane (HFC143a), 1,1,1,2-tetrafluoroethane (HFC134a), 1,1,1,2,2-pentafluoroethane (HFC125) and 1,1,1,3,3-pentafluoropropane (HFC245fa).
2010 Jan
Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices.
2010 Jun 28
Effect of repeated refrigerant spray applications using various carriers on pulpal temperature change.
2010 May-Jun
Symmetry measures of the electron density.
2010 Oct
Microscopic structure of liquid 1-1-1-2-tetrafluoroethane (R134a) from Monte Carlo simulation.
2010 Oct 28
Patents

Patents

Name Type Language
NORFLURANE
HSDB   II   INN   MART.   USAN   WHO-DD  
INN   USAN  
Official Name English
HFA-134A PROPELLANT
Code English
Norflurane [WHO-DD]
Common Name English
SOLKANE 134A
Brand Name English
HYDROFLUOROCARBON 134A
INCI  
INCI  
Official Name English
GENETRON 134A
Common Name English
FORANE 134A
Brand Name English
1,1,1,2-Tetrafluoroethane
Systematic Name English
norflurane [INN]
Common Name English
NORFLURANE [HSDB]
Common Name English
NORFLURANE [MART.]
Common Name English
FREON 134A
Common Name English
HFA 134A
Code English
R-134A
Code English
DYMEL 134A
Brand Name English
NORFLURANE [EP MONOGRAPH]
Common Name English
HFA-134-A
Code English
HYDROFLUOROCARBON 134A [INCI]
Common Name English
SUVA 134A
Common Name English
HFC-134A [MI]
Common Name English
NORFLURANE [USAN]
Common Name English
HFA-134A
Common Name English
NORFLURANE [II]
Common Name English
HFC-134A
MI  
Code English
TETRAFLUOROETHANE [VANDF]
Common Name English
ETHANE, 1,1,1,2-TETRAFLUORO-
Systematic Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 100895
Created by admin on Fri Dec 15 15:19:32 GMT 2023 , Edited by admin on Fri Dec 15 15:19:32 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID1021324
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PRIMARY
NCI_THESAURUS
C77482
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PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:19:32 GMT 2023 , Edited by admin on Fri Dec 15 15:19:32 GMT 2023
CONCEPT Industrial Aid
RXCUI
1311560
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PRIMARY RxNorm
CAS
811-97-2
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PRIMARY
ChEMBL
CHEMBL2104432
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PRIMARY
MESH
C063006
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PRIMARY
HSDB
6756
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PRIMARY
SMS_ID
100000083616
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PRIMARY
MERCK INDEX
m6020
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PRIMARY Merck Index
INN
2401
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PRIMARY
DRUG BANK
DB13116
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PRIMARY
ECHA (EC/EINECS)
212-377-0
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PRIMARY
PUBCHEM
13129
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PRIMARY
EVMPD
SUB09367MIG
Created by admin on Fri Dec 15 15:19:32 GMT 2023 , Edited by admin on Fri Dec 15 15:19:32 GMT 2023
PRIMARY
GRAS Notification (GRN No.)
82
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PRIMARY
DAILYMED
DH9E53K1Y8
Created by admin on Fri Dec 15 15:19:32 GMT 2023 , Edited by admin on Fri Dec 15 15:19:32 GMT 2023
PRIMARY
FDA UNII
DH9E53K1Y8
Created by admin on Fri Dec 15 15:19:32 GMT 2023 , Edited by admin on Fri Dec 15 15:19:32 GMT 2023
PRIMARY
WIKIPEDIA
1,1,1,2-Tetrafluoroethane
Created by admin on Fri Dec 15 15:19:32 GMT 2023 , Edited by admin on Fri Dec 15 15:19:32 GMT 2023
PRIMARY 1,1,1,2-tetrafluoroethane, R-134a, Forane 134a, Genetron 134a, Florasol 134a, Suva 134a or HFC-134a, also known as norflurane (INN), is a haloalkane refrigerant with thermodynamic properties similar to R-12 (dichlorodifluoromethane) but with insignificant ozone depletion potential. It has the formula CH2FCF3 and a boiling point of −26.3 ?C (−15.34 ?F) at atmospheric pressure. R-134a cylinders are colored light blue.[2] Attempts at phasing out its use as a refrigerant with substances that have lower global warming potentials, such as HFO-1234yf are underway.