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Details

Stereochemistry ACHIRAL
Molecular Formula C10H7Cl2NO
Molecular Weight 228.075
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLORQUINALDOL

SMILES

CC1=NC2=C(C=C1)C(Cl)=CC(Cl)=C2O

InChI

InChIKey=GPTXWRGISTZRIO-UHFFFAOYSA-N
InChI=1S/C10H7Cl2NO/c1-5-2-3-6-7(11)4-8(12)10(14)9(6)13-5/h2-4,14H,1H3

HIDE SMILES / InChI

Description

Chlorquinaldol is a halogenated hydroxyquinoline with properties similar to those of clioquinol. It is mainly applied topically in infected skin conditions and in vaginal infections. The product is applied for local treatment of cortico-sensitive dermatosis with moderately manifested superinfection, acute and subacute eczema, dermatitis, pyodermia, intertrigo, infected wounds, dermatomycosis, pemphigus in newborn. Chlorquinaldol is also used as antiseptic, fungistat, or deodorant. Chlorquinaldol is not commercially available in the U.S. but is used in other countries principally as an amebicide for nonspecific diarrheas and gynecologic infections. It is known most commonly under the proprietary name of Sterosan. Other trade names include Cynotherax, Gyno-Sterosan, Saprosan, Siogeno, Siosteran, Slosteran and Steroxin.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
10.1 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Chlorquinaldol
Curative
Gynosan Vaginal Pessary

PubMed

Sample Use Guides

In Vivo Use Guide
Applied in a thin layer on affected skin areas 1-3 times daily. Therapy duration is up to 8 days.
Route of Administration: Topical
In Vitro Use Guide
Chlorquinaldol displayed enhanced E. coli 205 bactericidal activity in human duodeno-pancreatic secretions with MIC 0.5ug/ml