Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2C11H17N3O.H2O4S |
| Molecular Weight | 512.623 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OS(O)(=O)=O.CNC(NCC1=CC=C(OC)C=C1)=NC.CNC(NCC2=CC=C(OC)C=C2)=NC
InChI
InChIKey=LVEGWDSAJVVBHT-UHFFFAOYSA-N
InChI=1S/2C11H17N3O.H2O4S/c2*1-12-11(13-2)14-8-9-4-6-10(15-3)7-5-9;1-5(2,3)4/h2*4-7H,8H2,1-3H3,(H2,12,13,14);(H2,1,2,3,4)
Meobentine is an antiarrhythmic agent. Meobentine significantly increases the electrical ventricular fibrillation threshold in animal models. Meobentine may prevent induction of ventricular tachycardia or fibrillation, or reduce frequency of complex ventricular ectopy in selected patients refractory to other antiarrhythmic agents, but the response rate is relatively low.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Studies on bethanidine and meobentine: direct and indirect effects of antifibrillatory drugs. | 1986-11-01 |
|
| Meobentine sulfate: antiarrhythmic and electrophysiologic effects assessed by programmed electrical stimulation and ambulatory monitoring in patients with complex ventricular tachyarrhythmia. Report of a multicenter evaluation. | 1985-10 |
|
| A comparison of the effects of bethanidine, meobentine and quinidine on the electrical activity of rat hearts in vivo and in vitro. | 1985-03 |
|
| The antiarrhythmic activity of meobentine sulfate in man. | 1984-07-01 |
|
| Antidysrhythmic actions of meobentine sulfate. | 1984-06 |
|
| Meobentine sulphate (bis[N-4-methoxybenzyl-N'N"-dimethylguanidine]sulphate): a new antidysrhythmic agent. | 1981-09 |
Patents
Sample Use Guides
intravenous (16 mg/kg); oral (400 to 1000 mg every 6 hours, 3 days/dose interval).
Route of Administration:
Other
Glass microelectrodes were used to record transmembrane electrical activity from cells located just beneath the endocardial surface of segments of the right ventricular free wall of the rat heart during superfusion and electrical stimulation in vitro at 37 degrees C. Meobentine (4 to 20 microM) applied in vitro caused a prolongation of action potential duration and a delayed and slowed return of electrical excitability following an action potential.
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NCI_THESAURUS |
C47793
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m7181
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42764
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C032896
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DTXSID10207225
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300000055260
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CHEMBL2110972
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C90664
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D6BKO039M0
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ACTIVE MOIETY
SUBSTANCE RECORD
