Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C13H22N6 |
| Molecular Weight | 262.354 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN[C@@H]1CCN(C1)C2=NC(N)=NC(NCC3CC3)=C2
InChI
InChIKey=ISBHYKVAFKTATD-SNVBAGLBSA-N
InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1
PF-03893787 is potent and selective histamine H4 receptor (H4R) antagonist. It has comparable binding affinity to the human histamine H3 receptor. PF-03893787 was found to have significant affinity for the hERG channel. Novartis initiates a phase II extension trial in Atopic dermatitis. Studies exploring the utility of PF-3893787 in patients would be reported in due course, being the potential indications of asthma, pruritus, inflammatory skin diseases and pain, among others.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787. | 2013 May 1 |
|
| Molecularly targeted therapies for asthma: Current development, challenges and potential clinical translation. | 2016 Oct |
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SUB194074
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D65H9YE9VU
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24745335
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C169765
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HI-100
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943057-12-3
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DB15027
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100000178346
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
