| Stereochemistry | MIXED |
| Molecular Formula | C19H32NO2 |
| Molecular Weight | 306.4629 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 3 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
CCC(C)C(C(=O)OCC[N+](C)(CC)CC)C1=CC=CC=C1
InChI
InChIKey=UPPMZCXMQRVMME-UHFFFAOYSA-N
InChI=1S/C19H32NO2/c1-6-16(4)18(17-12-10-9-11-13-17)19(21)22-15-14-20(5,7-2)8-3/h9-13,16,18H,6-8,14-15H2,1-5H3/q+1
Valethamate bromide ( sold under many brand names such as Epidosin, Dilaton, Valosin, Valamate, Osdil etc), a quarternary ammonium agent, has been used in augmentation of labor. Valethamate has antimuscarinic action and blocks cholinergic receptors in the ganglia. This action along with the direct action on the smooth muscles of the cervix is thought to help cervical dilatation during labor. Since it is not selective, it exerts anticholinergic side effects such as tachycardia, flushing, cotton mouth and photophobia due to mydriasis. Common side effects are palpitations, increased heart rate, arrhythmia, excessive thirst, reduced bronchial secretions, dry mouth, Photophobia, dry skin, loss of accommodation, slow heart rate, flushing.
Originator
Approval Year
Doses
AEs
Sourcing
PubMed
Patents
Sample Use Guides
Adult- PO- Per tab contains valethamate bromide 10 mg and paracetamol 325 mg: 1 tab 3 times/day.
IV/IM- 8-16 mg/day.
Route of Administration:
Other
The contraction of uterine horns from immature guinea pigs in response to methacholine (isotonic recording) was used for activity evaluztion. The uterine horns were suspended in an organ bath under 1 g resting tension and were superfused with SUND's physiological salt solution at a rate of 2 mi/min . After an equilibration period of 60 rain, 4 cumulative concentration-response curves to methacholine were obtained in each preparation at 60 or 90 min intervals. The first curve served as a control for the following curves which were carried out in the absence or presence of increasing concentrations of a given antagonist (60 or 90 min equilibration time).
ACTIVE MOIETY
