Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H23NO2.C4H4O4 |
| Molecular Weight | 413.4636 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)\C=C/C(O)=O.COC1=CC2=C(C=C1OC)[C@H](CN(C)CC2)C3=CC=CC=C3
InChI
InChIKey=TYNKKGLBKXZIHX-XLOMBBFOSA-N
InChI=1S/C19H23NO2.C4H4O4/c1-20-10-9-15-11-18(21-2)19(22-3)12-16(15)17(13-20)14-7-5-4-6-8-14;5-3(6)1-2-4(7)8/h4-8,11-12,17H,9-10,13H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-;/m1./s1
Trepipam is a benzazepine derivative. It is a D1-dopamine antagonist. Trepipam significantly reduced aggression in behaviorally disturbed adolescents and in acute schizophrenics without producing concomitant sedation. Trepipam specifically reduces aggressive and hyperactive behaviors in a wide range of laboratory tests in various species, without producing signs of overt CNS depression or neurological impairment. The drug is effective in reducing many forms of aggression including brain stimulated emotional behavior. Trepipam actually had little effect on gross behavior in mice or rats and only produced ataxia at lethal doses.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Pilot study of SCH-12679 in profoundly mentally retarded patients with severe behavior disorders]. | 1975 Jun |
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| Effects of a novel anti-aggressive agent upon two types of brain stimulated emotional behavior. | 1976 Jul 9 |
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| Effects of the phenethylamine derivatives, BL-3912, fenfluramine, and Sch-12679, in rats trained with LSD as a discriminative stimulus. | 1980 |
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| Comparison of SCH-12679 and thioridazine in aggressive mental retardates. | 1980 Oct |
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| Behavioural effects of psychoactive drugs on agonistic behaviour of male territorial rats (resident-intruder model). | 1984 |
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| Evidence that lack of brain dopamine during development can increase the susceptibility for aggression and self-injurious behavior by influencing D1-dopamine receptor function. | 1990 |
Patents
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C66884
Created by
admin on Fri Dec 15 15:15:43 GMT 2023 , Edited by admin on Fri Dec 15 15:15:43 GMT 2023
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| Code System | Code | Type | Description | ||
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CHEMBL343569
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D6074YC6T3
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6434250
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254-546-1
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39624-66-3
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C152729
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DTXSID3045803
Created by
admin on Fri Dec 15 15:15:43 GMT 2023 , Edited by admin on Fri Dec 15 15:15:43 GMT 2023
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PRIMARY |
ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
