MEDRYSONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H32O3
Molecular Weight	344.4877
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])C[C@H](C)C4=CC(=O)CC[C@]34C

InChI

InChIKey=GZENKSODFLBBHQ-ILSZZQPISA-N

InChI=1S/C22H32O3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h10,12,15-17,19-20,25H,5-9,11H2,1-4H3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1

HIDE SMILES / InChI

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/16624s41lbl.pdf

Medrysone is a synthetic glucocorticoid used to to treat inflammatory eye diseases such as allergic conjunctivitis, vernal conjunctivitis, and episcleritis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 172 Target ID: CHEMBL2034 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6336597	Agonist 2678

Conditions

Condition	Modality	Highest Phase	Product
Allergic conjunctivitis 100 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/16624s41lbl.pdf	Primary	Approved 8429	HMS Approved Use HMS (medrysone ophthalmic suspension) is a synthetic corticosteroid with topical anti-inflammatory activity. Corticoidsteroids inhibit the edema, fibrin deposition, capillary dilation, and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen, and scar formation. HMS (medrysone ophthalmic suspension) has less anti-inflammatory potency than 0.1% dexamethasone. Launch Date 1969
Vernal conjunctivitis 3 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/16624s41lbl.pdf	Primary	Approved 8429	HMS Approved Use HMS (medrysone ophthalmic suspension) is a synthetic corticosteroid with topical anti-inflammatory activity. Corticoidsteroids inhibit the edema, fibrin deposition, capillary dilation, and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen, and scar formation. HMS (medrysone ophthalmic suspension) has less anti-inflammatory potency than 0.1% dexamethasone. Launch Date 1969
Episcleritis 1 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/16624s41lbl.pdf	Primary	Approved 8429	HMS Approved Use HMS (medrysone ophthalmic suspension) is a synthetic corticosteroid with topical anti-inflammatory activity. Corticoidsteroids inhibit the edema, fibrin deposition, capillary dilation, and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen, and scar formation. HMS (medrysone ophthalmic suspension) has less anti-inflammatory potency than 0.1% dexamethasone. Launch Date 1969

Doses

Dose	Population	Adverse events
1 drop 12 times / day multiple, ophthalmic Dose: 1 drop, 12 times / day Route: ophthalmic Route: multiple Dose: 1 drop, 12 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/5554878	unhealthy, 44 years Health Status: unhealthy Age Group: 44 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/5554878	Disc. AE: Redness of eyelid, Swelling of eyelid... AEs leading to discontinuation/dose reduction: Redness of eyelid (1 patient) Swelling of eyelid (1 patient) Itching eyes (severe, 1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/5554878

AEs

AE	Significance	Dose	Population
Redness of eyelid	1 patient Disc. AE	1 drop 12 times / day multiple, ophthalmic Dose: 1 drop, 12 times / day Route: ophthalmic Route: multiple Dose: 1 drop, 12 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/5554878	unhealthy, 44 years Health Status: unhealthy Age Group: 44 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/5554878
Swelling of eyelid	1 patient Disc. AE	1 drop 12 times / day multiple, ophthalmic Dose: 1 drop, 12 times / day Route: ophthalmic Route: multiple Dose: 1 drop, 12 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/5554878	unhealthy, 44 years Health Status: unhealthy Age Group: 44 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/5554878
Itching eyes	severe, 1 patient Disc. AE	1 drop 12 times / day multiple, ophthalmic Dose: 1 drop, 12 times / day Route: ophthalmic Route: multiple Dose: 1 drop, 12 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/5554878	unhealthy, 44 years Health Status: unhealthy Age Group: 44 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/5554878

Sourcing

Vendor/Aggregator	ID	URL
AA Blocks	AA00BDZM	https://www.aablocks.com/goods/Goods/detail?id=AA00BDZM
AK Scientific, Inc. (AKSCI)	2534AH	http://www.aksci.com/item_detail.php?cat=2534AH
Aurora Fine Chemicals LLC	A17.877.133	http://online.aurorafinechemicals.com/info?ID=A17.877.133
Chem Scene	CS-4632	http://www.chemscene.com/2668-66-8.html
ChemMol	99067044	http://www.chemmol.com/chemmol/99067044.html
Chemspace	CSSB00000075797	https://chem-space.com/CSSB00000075797
DC Chemicals	DC36916	http://www.dcchemicals.com//product_show-Medrysone.html
Hairui	HR141107	http://www.hairuichem.com/en/product/2668-66-8.html
MedChem Express	HY-B1076	https://www.medchemexpress.com/Medrysone.html
MuseChem	I002915	https://www.musechem.com/product/I002915.html
OChem	30712	http://www.ocheminc.com/index.php?act=psearch&pid=668M668
Sigma-Aldrich	1379004_USP	http://www.sigmaaldrich.com/catalog/product/usp/1379004?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	M0388_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/m0388?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S534894	http://www.smolecule.com/products/s534894
THE BioTek	bt-274615	https://www.thebiotek.com/product/inhibitors/bt-274615

PubMed

Title	Date	PubMed
Little evidence for association of the glaucoma gene MYOC with open-angle glaucoma.	2010 May	20447966

Patents

Sample Use Guides

In Vivo Use Guide

One drop of medrysone eye drops should be instilled into the conjunctival sac up to every four hours.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

MEDRYSONE

Official Name

English

MEDRYSONE [MI]

Common Name

English

MEDRYSONE [VANDF]

Common Name

English

MEDRYSONE [ORANGE BOOK]

Common Name

English

NSC-63278

Code

English

U-8471

Code

English

MEDRYSONE [USAN]

Common Name

English

MEDRYSONE [MART.]

Common Name

English

medrysone [INN]

Common Name

English

11β-Hydroxy-6α-methylpregn-4-ene-3,20-dione

Systematic Name

English

Medrysone [WHO-DD]

Common Name

English

PREGN-4-ENE-3,20-DIONE, 11-HYDROXY-6-METHYL-, (6.ALPHA.,11.BETA.)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521