3,6-DIMETHYLMANGOSTIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H30O6
Molecular Weight	438.5128
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C(=O)C3=C(O2)C=C(OC)C(OC)=C3CC=C(C)C)C(O)=C1CC=C(C)C

InChI

InChIKey=FCIKYGUVHWZSJV-UHFFFAOYSA-N

InChI=1S/C26H30O6/c1-14(2)8-10-16-18(29-5)12-20-23(24(16)27)25(28)22-17(11-9-15(3)4)26(31-7)21(30-6)13-19(22)32-20/h8-9,12-13,27H,10-11H2,1-7H3

HIDE SMILES / InChI

Description
Sources: http://www.hmdb.ca/metabolites/HMDB36597 | https://www.ncbi.nlm.nih.gov/pubmed/25651042

3,6-DIMETHYLMANGOSTIN (Fuscaxanthone C) is a constituent of Garcinia mangostana (mangosteen). Fuscaxanthone C has shown α-glucosidase inhibitory activity.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Alpha-glucosidase MAL62 4 Target ID: CHEMBL4357 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25651042	Inhibitor 8504
Bacillus subtilis 9 Target ID: CHEMBL359 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25651042	Inhibitor 8504
Pseudomonas aeruginosa 12 Target ID: CHEMBL348 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25651042	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bacterial infections 235 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25651042	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Cytotoxic constituents from Cratoxylum arborescens.	2005-02	15729629
Chemical constituents of Garcinia fusca: structure elucidation of eight new xanthones and their cancer chemopreventive activity.	2003-02	12608849

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Fuscaxanthone C showed 53.8% inhibition of α-glucosidase activity at a concentration of 100 uM.

Name

Type

Language

3,6-DIMETHYLMANGOSTIN

Common Name

English

FUSCAXANTHONE C

Preferred Name

English

MANGOSTIN, DIMETHYL-

Common Name

English

XANTHEN-9-ONE, 1-HYDROXY-3,6,7-TRIMETHOXY-2,8-BIS(3-METHYL-2-BUTENYL)-

Systematic Name

English

1-HYDROXY-3,6,7-TRIMETHOXY-2,8-BIS-(3-METHYL-2-BUTEN-1-YL)-9H-XANTHEN-9-ONE

Systematic Name

English

9H-XANTHEN-9-ONE, 1-HYDROXY-3,6,7-TRIMETHOXY-2,8-BIS(3-METHYL-2-BUTEN-1-YL)-

Systematic Name

English

NSC-27594

Code

English

3,6-DIMETHYLMANGOSTIN [MI]

Common Name

English

Code System Code Type Description

PUBCHEM

231412