POSELTINIB

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H26N6O3
Molecular Weight	470.523
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CN1CCN(CC1)C2=CC=C(NC3=NC4=C(OC=C4)C(OC5=CC(NC(=O)C=C)=CC=C5)=N3)C=C2

InChI

InChIKey=LZMJNVRJMFMYQS-UHFFFAOYSA-N

InChI=1S/C26H26N6O3/c1-3-23(33)27-19-5-4-6-21(17-19)35-25-24-22(11-16-34-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30)

HIDE SMILES / InChI

Approval Year

C_max

Value	Dose	Analyte	Population
11.5 ng/mL	5 mg single, oral	POSELTINIB plasma	Homo sapiens
56.5 ng/mL	30 mg single, oral	POSELTINIB plasma	Homo sapiens
186 ng/mL	80 mg single, oral	POSELTINIB plasma	Homo sapiens
358 ng/mL	160 mg single, oral	POSELTINIB plasma	Homo sapiens
65.8 ng/mL	30 mg 1 times / day steady-state, oral	POSELTINIB plasma	Homo sapiens
201 ng/mL	30 mg 1 times / day multiple, oral	POSELTINIB plasma	Homo sapiens

AUC

Value	Dose	Analyte	Population
84.8 ng × h/mL	5 mg single, oral	POSELTINIB plasma	Homo sapiens
276 ng × h/mL	30 mg single, oral	POSELTINIB plasma	Homo sapiens
1040 ng × h/mL	80 mg single, oral	POSELTINIB plasma	Homo sapiens
2100 ng × h/mL	160 mg single, oral	POSELTINIB plasma	Homo sapiens
368 ng × h/mL	30 mg 1 times / day steady-state, oral	POSELTINIB plasma	Homo sapiens
1347 ng × h/mL	30 mg 1 times / day multiple, oral	POSELTINIB plasma	Homo sapiens

T_1/2

Value	Dose	Co-administered	Analyte	Population
5.6 h	30 mg 1 times / day multiple, oral		POSELTINIB plasma	Homo sapiens

Show entries

Name

Type

Language

POSELTINIB

Official Name

English

poseltinib [INN]

Preferred Name

English

HM71224

Code

English

Poseltinib [WHO-DD]

Common Name

English

N-(3-((2-(4-(4-METHYLPIPERAZIN-1-YL)ANILINO)FURO(3,2-D)PYRIMIDIN-4-YL)OXY)PHENYL)PROP-2-ENAMIDE

Systematic Name

English

Showing 1 to 5 of 7 entries

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Classification Tree

Code System

Code

Tyrosine Kinase Inhibitor

NCI_THESAURUS

C124801

Showing 1 to 1 of 1 entries

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Show entries

Code System

Code

Type

Description

CAS

1353552-97-2

PRIMARY

EPA CompTox

DTXSID501112972

PRIMARY

INN

10235

PRIMARY

WIKIPEDIA

Poseltinib

PRIMARY

NCI_THESAURUS

C141273

PRIMARY

Showing 1 to 5 of 8 entries

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ACTIVE MOIETY


					D01E4B1U35

POSELTINIB

SMILES

InChI

Approval Year

Cmax

AUC

T1/2

C_max

T_1/2