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Details

Stereochemistry RACEMIC
Molecular Formula C11H13NO4
Molecular Weight 223.2252
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEPHENOXALONE

SMILES

COC1=C(OCC2CNC(=O)O2)C=CC=C1

InChI

InChIKey=ZMNSRFNUONFLSP-UHFFFAOYSA-N
InChI=1S/C11H13NO4/c1-14-9-4-2-3-5-10(9)15-7-8-6-12-11(13)16-8/h2-5,8H,6-7H2,1H3,(H,12,13)

HIDE SMILES / InChI

Description

Mephenoxalone is an oxazolidinone compound. It is a skeletal muscle relaxant as well as anxiolytic. Mephenoxalone is indicated for the treatment of muscle spasms.

CNS Activity

Originator

Robins, A.H.
5
Curator's Comment: reference retrieved from http://www.arkat-usa.org/get-file/22989/

Approval Year

1961
146
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
DORSIFLEX

Approved Use

Mephenoxalone is indicated for the treatment of muscle spasms
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
2849 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/11499633/
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
MEPHENOXALONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
16274 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/11499633/
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
MEPHENOXALONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.77 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/11499633/
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
MEPHENOXALONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
MATE1
135
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
MATE1
135
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY567901
https://www.001chemical.com/chem/70-07-5
AA Blocks
AA00F9Z4
https://www.aablocks.com/goods/Goods/detail?id=AA00F9Z4
AHH Chemical co.,ltd
MR-1008644
http://www.ahhchemical.com/product/MR-1008644.html
Achemtek
0102-026474
http://www.achemtek.com/70-07-5
Ambinter
Amb17616769
http://www.ambinter.com/reference/17616769
Aurora Fine Chemicals LLC
A24.076.948
http://online.aurorafinechemicals.com/info?ID=A24.076.948
BLD Pharm
BD105769
http://www.bldpharm.com/products/70-07-5.html
BOC Sciences
70-07-5
https://www.bocsci.com/mephenoxalone-cas-70-07-5-item-13310.html
Chemenu
CM128782
http://www.chemenu.com/products/CM128782
Chemspace
CSSB00000019079
https://chem-space.com/CSSB00000019079
Finetech
FT-0671011
http://www.finetechnology-ind.com/prod/detail/pub/70-07-5.html
Hairui
HR141972
http://www.hairuichem.com/en/product/70-07-5.html
Lab Network
LN01286367
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01286367
Molcore
MC567901
https://www.molcore.com/product/70-07-5
OChem
11970
http://www.ocheminc.com/index.php?act=psearch&pid=070M075
Sigma-Aldrich
PH016119_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/ph016119?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule
S793367
https://www.smolecule.com/products/s793367
eNovation Chemicals
D280452
https://www.enovationchem.com/ProductDetails.asp?ProductID=D280452
iChemical
EBD37900
http://www.ichemical.com/chemicals/cas-70-07-5
PubMed

PubMed

TitleDatePubMed
Use of mephenoxalone in behavioral problems.
1962 Mar
Patents

Patents

JP2001247581A
1
JP2002145879A
3
JP2005515029A
3
JP2006504850A
2
JP2008510795A
76
JP2013241455A
1
JPH00959265A
4
JPH06116537A
1
JPH06128186A
1
JPH07258232A
1
JPH07309850A
1
JPH08109173A
1
JPH0841038A
1
JPH09194478A
1
JPS5931693A
1

Sample Use Guides

In Vivo Use Guide
Adult: 200-400 mg tid.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
MEPHENOXALONE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
MEPHENOXALONE [MART.]
Common Name English
AHR-233
Code English
METHOXADONE
Common Name English
OM-518
Code English
METOXADONE
Common Name English
MEPHENOXALONE [MI]
Common Name English
METHOXYDONE
Common Name English
5-((2-METHOXYPHENOXY)METHYL)-2-OXAZOLIDINONE
Systematic Name English
MEFENOXALONE
Common Name English
5-((O-METHYLPHENOXY)METHYL)-2-OXAZOLIDINONE
Common Name English
DORSIFLEX
Brand Name English
mephenoxalone [INN]
Common Name English
Mephenoxalone [WHO-DD]
Common Name English
5-(O-METHOXYPHENOXYMETHYL)-2-OXAZOLIDINONE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29696
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
WHO-VATC QN05BX01
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
WHO-ATC N05BX01
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
Code System Code Type Description
FDA UNII
CZ87T54W8W
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
CAS
70-07-5
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
INN
973
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
MERCK INDEX
m7188
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C83930
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
DRUG CENTRAL
1693
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
SMS_ID
100000092405
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
PUBCHEM
6257
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
DRUG BANK
DB13754
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
EPA CompTox
DTXSID9023255
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-723-3
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
ChEMBL
CHEMBL2104790
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
WIKIPEDIA
MEPHENOXALONE
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
EVMPD
SUB08747MIG
Created by admin on Fri Dec 15 15:12:46 UTC 2023 , Edited by admin on Fri Dec 15 15:12:46 UTC 2023
PRIMARY
ACTIVE MOIETY
Structure of MEPHENOXALONE
NIH
NCATS
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