MEPHENOXALONE

US Previously Marketed

First approved in 1961

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H13NO4
Molecular Weight	223.2252
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=CC=C1OCC2CNC(=O)O2

InChI

InChIKey=ZMNSRFNUONFLSP-UHFFFAOYSA-N

InChI=1S/C11H13NO4/c1-14-9-4-2-3-5-10(9)15-7-8-6-12-11(13)16-8/h2-5,8H,6-7H2,1H3,(H,12,13)

HIDE SMILES / InChI

Description
Sources: https://www.lekarna.cz/dorsiflex-200mg-tbl-30x200mg/ | http://www.arkat-usa.org/get-file/22989/

Mephenoxalone is an oxazolidinone compound. It is a skeletal muscle relaxant as well as anxiolytic. Mephenoxalone is indicated for the treatment of muscle spasms.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Muscle spasm 41 Sources: https://www.lekarna.cz/dorsiflex-200mg-tbl-30x200mg/ https://www.ndrugs.com/?s=mephenoxalone	Primary		Approved 8583	DORSIFLEX Approved Use Mephenoxalone is indicated for the treatment of muscle spasms

C_max

Value	Dose	Co-administered	Analyte	Population
2849 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11499633/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:		MEPHENOXALONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
16274 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11499633/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:		MEPHENOXALONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
2.77 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11499633/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:		MEPHENOXALONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	MATE1 182

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
MATE1 182	substrate 4014 Sources: https://bioinformatics.charite.de/transformer/index.php?site=fullinfo&cname=000070075	yes

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY567901	https://www.001chemical.com/chem/70-07-5
AA Blocks	AA00F9Z4	https://www.aablocks.com/goods/Goods/detail?id=AA00F9Z4
Achemtek	0102-026474	http://www.achemtek.com/70-07-5
AHH Chemical co.,ltd	MR-1008644	http://www.ahhchemical.com/product/MR-1008644.html
Ambinter	Amb17616769	http://www.ambinter.com/reference/17616769
Aurora Fine Chemicals LLC	A24.076.948	http://online.aurorafinechemicals.com/info?ID=A24.076.948
BLD Pharm	BD105769	http://www.bldpharm.com/products/70-07-5.html
BOC Sciences	70-07-5	https://www.bocsci.com/mephenoxalone-cas-70-07-5-item-13310.html
Chemenu	CM128782	http://www.chemenu.com/products/CM128782
Chemspace	CSSB00000019079	https://chem-space.com/CSSB00000019079
eNovation Chemicals	D280452	https://www.enovationchem.com/ProductDetails.asp?ProductID=D280452
Finetech	FT-0671011	http://www.finetechnology-ind.com/prod/detail/pub/70-07-5.html
Hairui	HR141972	http://www.hairuichem.com/en/product/70-07-5.html
iChemical	EBD37900	http://www.ichemical.com/chemicals/cas-70-07-5
Lab Network	LN01286367	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01286367
Molcore	MC567901	https://www.molcore.com/product/70-07-5
OChem	11970	http://www.ocheminc.com/index.php?act=psearch&pid=070M075
Sigma-Aldrich	PH016119_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/ph016119?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S793367	https://www.smolecule.com/products/s793367

PubMed

Title	Date	PubMed
[Results of using Dorsiflex in various neurologic diseases in children].	1989-02-15	2696209
Use of mephenoxalone in behavioral problems.	1962-03	14459221

Patents

Sample Use Guides

In Vivo Use Guide

Adult: 200-400 mg tid.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

MEPHENOXALONE

Official Name

English

DORSIFLEX

Preferred Name

English

MEPHENOXALONE [MART.]

Common Name

English

AHR-233

Code

English

METHOXADONE

Common Name

English

OM-518

Code

English

METOXADONE

Common Name

English

MEPHENOXALONE [MI]

Common Name

English

METHOXYDONE

Common Name

English

5-((2-METHOXYPHENOXY)METHYL)-2-OXAZOLIDINONE

Systematic Name

English

MEFENOXALONE

Common Name

English

5-((O-METHYLPHENOXY)METHYL)-2-OXAZOLIDINONE

Common Name

English

mephenoxalone [INN]

Common Name

English

Mephenoxalone [WHO-DD]

Common Name

English

5-(O-METHOXYPHENOXYMETHYL)-2-OXAZOLIDINONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29696