ROMIDEPSIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H36N4O6S2
Molecular Weight	540.696
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of ROMIDEPSIN

Structure Search

SMILES

[H][C@]12CC(=O)N[C@H](C(C)C)C(=O)N[C@]([H])(CSSCC\C=C\1)C(=O)N\C(=C/C)C(=O)N[C@@H](C(C)C)C(=O)O2

InChI

InChIKey=OHRURASPPZQGQM-GCCNXGTGSA-N

InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1

HIDE SMILES / InChI

Description
Sources: https://pubmed.ncbi.nlm.nih.gov/26331334

FR-135313 (also known as Romidepsin reduced) was studied as a selective inhibitor of the human histone deacetylase 1 (HDAC1).

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Histone deacetylase 1 51 Target ID: Q13547 Gene ID: 3065.0 Gene Symbol: HDAC1 Target Organism: Homo sapiens (Human) Sources: https://pubmed.ncbi.nlm.nih.gov/26331334	Inhibitor 8297		0.12 nM [IC50]

Sample Use Guides

In Vitro Use Guide

Inhibition of recombinant human HDAC1 after 60 mins by fluorescence assay with IC50 = 0.00012 uM

Name

Type

Language

ROMIDEPSIN

Official Name

English

FK-228

Code

English

ROMIDEPSIN [MART.]

Common Name

English

CHROMADAX

Brand Name

English

(1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone

Systematic Name

English

ROMIDEPSIN [JAN]

Common Name

English

CYCLO((2Z)-2-AMINO-2-BUTENOYL-L-VALYL-(3S,4E)-3-HYDROXY-7-MERCAPTO-4-HEPTENOYL-D-VALYL-D-CYSTEINYL), CYCLIC (3->5)-DISULFIDE

Common Name

English

Depsipeptide [WHO-DD]

Common Name

English

DEPSIPEPTIDE

Common Name

English

FK228

Code

English

ROMIDEPSIN [MI]

Common Name

English

Romidepsin [WHO-DD]

Common Name

English

ROMIDEPSIN [USAN]

Common Name

English

romidepsin [INN]

Common Name

English

ROMIDEPSIN [ORANGE BOOK]

Common Name

English

ISTODAX

Brand Name

English

NSC-630176

Code

English

ROMIDEPSIN [VANDF]

Common Name

English

FR-901228

Code

English

FR901228

Code

English

CYCLO((2Z)-2-AMINO-2-BUTENOYL-L-VALYL-(3S,4E)-3-HYDROXY-7-MERCAPTO-4-HEPTENOYL-D-VALYL-D-CYSTEINYL), CYCLIC (3->5)-DISULPHIDE

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

193404

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

EMA ASSESSMENT REPORTS

ISTODAX (REFUSED: LYMPHOMA, NON-HODGKIN)

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

NCI_THESAURUS

C1946

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

WHO-ATC

L01XX39

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

LIVERTOX

NBK548380

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

NDF-RT

N0000175588

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

WHO-VATC

QL01XX39

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

NCI_THESAURUS

C1976

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

Code System Code Type Description

INN

8656

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

PRIMARY

MERCK INDEX

m9652

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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Merck Index

NSC

630176

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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EVMPD

SUB26362

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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USAN

SS-77

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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DAILYMED

CX3T89XQBK

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

PRIMARY

EU-Orphan Drug

EU/3/05/279(POSITIVE)

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

PRIMARY

On 27 May 2005, orphan designation (EU/3/05/279) was granted by the European Commission to The Matthews Consultancy Ltd, United Kingdom, for (E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone (depsipeptide) for the treatment of cutaneous T cell lymphoma. The sponsorship was transferred to Gloucester Pharmaceuticals Limited, United Kingdom, in October 2008 and to Celgene Europe Limited, United Kingdom, in September 2010.

CHEBI

61080

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

PRIMARY

MESH

C087123

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

PRIMARY

EU-Orphan Drug

EU/3/05/328(POSITIVE)

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

PRIMARY

On 28 October 2005, orphan designation (EU/3/05/328) was granted by the European Commission to The Matthews Consultancy Ltd, United Kingdom, for (E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone (also known as “depsipeptide”) for the for the treatment of peripheral T-cell lymphoma (nodal, other extranodal and leukaemic/disseminated). The sponsorship was transferred to Gloucester Pharmaceuticals Limited, United Kingdom, in October 2008 and to Celgene Europe Limited, United Kingdom, in September 2010.

ChEMBL

CHEMBL1213490

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

PRIMARY

IUPHAR

7006

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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SMS_ID

100000091284

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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FDA UNII

CX3T89XQBK

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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RXCUI

877510

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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RxNorm

EPA CompTox

DTXSID8048579

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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WIKIPEDIA

ROMIDEPSIN

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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NCI_THESAURUS

C1544

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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PUBCHEM

5352062

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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DRUG BANK

DB06176

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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DRUG CENTRAL

4119

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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CAS

128517-07-7

Created by admin on Fri Dec 15 15:47:36 GMT 2023 , Edited by admin on Fri Dec 15 15:47:36 GMT 2023

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ACTIVE MOIETY


					4MQ5UQAIB8

FR-135313

SUBSTANCE RECORD


					CX3T89XQBK