ACETOXOLONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C32H48O5
Molecular Weight	512.7205
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)C1(C)C

InChI

InChIKey=FTQDJVZNPJRVPG-XWEVEMRCSA-N

InChI=1S/C32H48O5/c1-19(33)37-24-10-11-30(6)23(27(24,2)3)9-12-32(8)25(30)22(34)17-20-21-18-29(5,26(35)36)14-13-28(21,4)15-16-31(20,32)7/h17,21,23-25H,9-16,18H2,1-8H3,(H,35,36)/t21-,23-,24-,25+,28+,29-,30-,31+,32+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4006763

There is a little information about acetoxolone. It is known, that this drug is an acetyl derivative of the glycyrrhetinic acid, which is used to treat peptic ulcer.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Ulcer 5 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4006763	Primary		Not Provided 511	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.	2012-05-15	22520261
[Treatment of ulcer with acetoxolon].	1985-06-28	4006763
[Measuring the potential difference of gastric mucosa as a means of quantifying the protective effect of Al-acetylglycyrrhetinate after a dose of acetylsalicylic acid (author's transl)].	1981	7196748

Patents

Sample Use Guides

In Vivo Use Guide

predosed: 100 mg

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

ACETOXOLONE

Common Name

English

DGS 0110A

Preferred Name

English

URALENIC ACID, ACETATE

Common Name

English

Acetoxolone [WHO-DD]

Common Name

English

ACETYLGLYCYRRHETIC ACID

Common Name

English

ACETOXOLONE [MI]

Common Name

English

GLYCYRRHETIC ACID ACETATE

Common Name

English

3-O-ACETYL-18.BETA.-GLYCYRRHETIC ACID

Common Name

English

NSC-35349

Code

English

GLYCYRRHETINIC ACID ACETATE

Common Name

English

GLYCYRRHETINYL ACETATE

Common Name

English

3.BETA.-HYDROXY-11-OXOOLEAN-12-EN-30-OIC ACID ACETATE

Common Name

English

OLEAN-12-EN-29-OIC ACID, 3-(ACETYLOXY)-11-OXO-, (3.BETA.,20.BETA.)-

Common Name

English

ACETYLGLYCYRRHETINIC ACID

Common Name

English

(3.BETA.,20.BETA.)-3-(ACETYLOXY)-11-OXOOLEAN-12-EN-29-OIC ACID

Common Name

English

DGS-0110A

Code

English

Classification Tree Code System Code

WHO-ATC

A02BX09