U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C10H17NO2
Molecular Weight 183.2475
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METHYPRYLON

SMILES

CCC1(CC)C(=O)NCC(C)C1=O

InChI

InChIKey=SIDLZWOQUZRBRU-UHFFFAOYSA-N
InChI=1S/C10H17NO2/c1-4-10(5-2)8(12)7(3)6-11-9(10)13/h7H,4-6H2,1-3H3,(H,11,13)

HIDE SMILES / InChI
Methyprylon (brand name Noludar) is a sedative agent, which used to treat insomnia. But then the drug was replaced in the market by another drugs with less side effects. The precise mechanism of action is not known, but was made suggestion, that methyprylon increases the effects of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain.

Originator

Sources: US2680116 A
Curator's Comment: # Hoffmann-La Roche

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
NOLUDAR

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
5.62 mg/L
300 mg single, oral
dose: 300 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
METHYPRYLON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
74.75 mg × h/L
300 mg single, oral
dose: 300 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
METHYPRYLON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
9.2 h
300 mg single, oral
dose: 300 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
METHYPRYLON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
30 g single, oral
Overdose
Dose: 30 g
Route: oral
Route: single
Dose: 30 g
Co-administed with::
dimenhydrinate(one hundred 50-mg capsules)
Sources:
unhealthy, 36 years
n = 1
Health Status: unhealthy
Age Group: 36 years
Sex: F
Population Size: 1
Sources:
Other AEs: Comatose...
Other AEs:
Comatose (1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Comatose 1 patient
30 g single, oral
Overdose
Dose: 30 g
Route: oral
Route: single
Dose: 30 g
Co-administed with::
dimenhydrinate(one hundred 50-mg capsules)
Sources:
unhealthy, 36 years
n = 1
Health Status: unhealthy
Age Group: 36 years
Sex: F
Population Size: 1
Sources:
PubMed

PubMed

TitleDatePubMed
Hypnotic efficacy of triazolam and methyprylon ininsomniac in-patients.
1976
Pharmacokinetics of methyprylon following a single oral dose.
1985 Sep
Patents

Patents

Sample Use Guides

In Vivo Use Guide
300 mg once a day before bedtime.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
METHYPRYLON
HSDB   INN   JAN   MART.   MI   ORANGE BOOK   VANDF   WHO-DD  
INN  
Official Name English
methyprylon [INN]
Common Name English
METHYPRYLON [HSDB]
Common Name English
METHYPRYLON [ORANGE BOOK]
Common Name English
METHYPRYLON [JAN]
Common Name English
NOLUDAR
Brand Name English
NSC-30442
Code English
METHYPRYLON [MI]
Common Name English
METHYPRYLONE
Common Name English
Methyprylon [WHO-DD]
Common Name English
METHYPRYLON [MART.]
Common Name English
3,3-Diethyl-5-methyl-2,4-piperidinedione
Systematic Name English
METHYPRYLON [VANDF]
Common Name English
2,4-PIPERIDINEDIONE, 3,3-DIETHYL-5-METHYL-
Systematic Name English
Classification Tree Code System Code
WHO-VATC QN05CE02
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
NCI_THESAURUS C29756
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
DEA NO. 2575
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
WHO-ATC N05CE02
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
Code System Code Type Description
RXCUI
6910
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID7023306
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PRIMARY
HSDB
3128
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY
NCI_THESAURUS
C66122
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY
NSC
30442
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY
PUBCHEM
4162
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PRIMARY
INN
287
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PRIMARY
WIKIPEDIA
METHYPRYLON
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY
EVMPD
SUB08879MIG
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY
ChEMBL
CHEMBL1200790
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY
DRUG CENTRAL
1774
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PRIMARY
DRUG BANK
DB01107
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY
ECHA (EC/EINECS)
204-745-4
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY
MERCK INDEX
m7482
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY Merck Index
IUPHAR
7238
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY
CAS
125-64-4
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY
SMS_ID
100000080891
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY
FDA UNII
CUT48I42ON
Created by admin on Fri Dec 15 16:31:08 GMT 2023 , Edited by admin on Fri Dec 15 16:31:08 GMT 2023
PRIMARY