| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H14FN3O |
| Molecular Weight | 283.3003 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=C(C=CC=C1)N2C(=O)C3=CC(N)=CC=C3N=C2CF
InChI
InChIKey=VDOSWXIDETXFET-UHFFFAOYSA-N
InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3
Afloqualone (AFQ) is one of the centrally acting muscle relaxants. It is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku. It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABAa receptor, and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis.
CNS Activity
Originator
Approval Year
PubMed
Patents
ACTIVE MOIETY
