U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C12H11I3N2O4
Molecular Weight 627.9402
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METRIZOIC ACID

SMILES

CN(C(C)=O)C1=C(I)C(C(O)=O)=C(I)C(NC(C)=O)=C1I

InChI

InChIKey=GGGDNPWHMNJRFN-UHFFFAOYSA-N
InChI=1S/C12H11I3N2O4/c1-4(18)16-10-7(13)6(12(20)21)8(14)11(9(10)15)17(3)5(2)19/h1-3H3,(H,16,18)(H,20,21)

HIDE SMILES / InChI

Description

Metrizoic acid is a diagnostic radiopaque that usually occurs as the sodium salt. The mechanism of action of metrizoic acid is as a X-Ray Contrast Activity.

Originator

Approval Year

1973
95
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Approved
8583
ISOPAQUE 280

Approved Use

Unknown

Launch Date

1974
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
300 μg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/3375780/
2310 mg single, intravenous
dose: 2310 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
METRIZOIC ACID serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
250 μg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/3375780/
2310 mg single, intravenous
dose: 2310 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
METRIZOIC ACID serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
75.1 min
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/3375780/
2310 mg single, intravenous
dose: 2310 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
METRIZOIC ACID serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
100%
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/3375780/
2310 mg single, intravenous
dose: 2310 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
METRIZOIC ACID serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:34847
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:34847
ChemicalBook
CB1775662
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB1775662
eMolecules
736293
https://www.emolecules.com/cgi-bin/more?vid=736293
MolPort
MolPort-006-147-732
https://www.molport.com/shop/molecule-link/MolPort-006-147-732
ZINC
ZINC000003831116
http://zinc15.docking.org/substances/ZINC000003831116
PubMed

PubMed

TitleDatePubMed
Enrichment and analysis of secretory lysosomes from lymphocyte populations.
2009-07-29
Acute renal failure in rats. Interaction between contrast media and temporary renal arterial occlusion.
1989-05-01
Selective injection of iopentol, iohexol and metrizoate into the left coronary artery of the dog. Induction of ventricular fibrillation and decrease of aortic pressure.
1987
ECG changes and arrhythmias induced by ionic and non-ionic contrast media during coronary arteriography in dogs.
1978-05-01
Adverse general reactions to high doses of methylglucamine-based contrast media.
1974-09
Increased ventricular fibrillation during coronary arteriography with a new contrast medium preparation.
1971-10

Sample Use Guides

In Vivo Use Guide
0.35 mg/ml; 140.1 mg/ml; 461.8 mg/ml
Route of Administration: Intravascular
In Vitro Use Guide
Unknown
Name Type Language
METRIZOIC ACID
MART.   MI   ORANGE BOOK   WHO-DD  
Common Name English
V08AA02
Preferred Name English
Metrizoic acid [WHO-DD]
Common Name English
BENZOIC ACID, 3-(ACETYLAMINO)-5-(ACETYLMETHYLAMINO)-2,4,6-TRIIODO-
Common Name English
3-ACETAMIDO-2,4,6-TRI-IODO-5-(N-METHYLACETAMIDO)BENZOIC ACID
Systematic Name English
METRIZOIC ACID [JAN]
Common Name English
METRIZOIC ACID [MART.]
Common Name English
METRIZOIC ACID [MI]
Common Name English
METRIZOIC ACID [ORANGE BOOK]
Common Name English
Classification Tree Code System Code
NDF-RT N0000010258
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
WHO-ATC V08AA02
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
NDF-RT N0000180185
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
WHO-VATC QV08AA02
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
NCI_THESAURUS C390
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
Code System Code Type Description
DRUG BANK
DB09346
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
SMS_ID
100000085979
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
EPA CompTox
DTXSID6023311
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
ECHA (EC/EINECS)
217-761-1
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
NCI_THESAURUS
C76635
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
DRUG CENTRAL
1789
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
CHEBI
34847
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
ChEMBL
CHEMBL1736
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
CAS
1949-45-7
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
MERCK INDEX
m7505
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY Merck Index
PUBCHEM
2528
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
WIKIPEDIA
Metrizoic acid
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
EVMPD
SUB03276MIG
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
FDA UNII
CM1N99QR1M
Created by admin on Mon Mar 31 17:33:54 GMT 2025 , Edited by admin on Mon Mar 31 17:33:54 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of METRIZOIC ACID
SALT/SOLVATE (PARENT)
Structure of METRIZOATE CALCIUM
SALT/SOLVATE (PARENT)
Structure of METRIZOATE MEGLUMINE
SALT/SOLVATE (PARENT)
Structure of METRIZOATE SODIUM
SALT/SOLVATE (PARENT)
Structure of METRIZOATE MAGNESIUM
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966